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Fig. 2 | BMC Endocrine Disorders

Fig. 2

From: Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells

Fig. 2

Role of HIF-1α in protecting AtT-20 cells from hypoxia-induced apoptosis. AtT-20 cells were transfected with 10 μM HIF-1α siRNA or mock transfected, and subsequently cultured in hypoxic or normoxic conditions for 12h. (a) Annexin V-FITC and (b) TUNEL assay showed increased apoptosis when cells were transfected with HIF-1α siRNA and subsequently cultured in 1% O2 for 12 h compared with normoxia and mock groups (*P < 0.05 vs.the other groups)

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BMC Endocrine Disorders

ISSN: 1472-6823

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