Glucose tolerance test (GTT) and insulin tolerance test (ITT) performed on the Apoe−/−mice after being exposed to phthalate for 2 and 3 weeks, respectively. For GTT, mice were fasted overnight and then subject to an intraperitoneal injection of glucose (1 g/kg). ITT was performed on non-fasted mice with an intraperitoneal injection of insulin (0.75 U/kg). Blood glucose concentrations were determined with a glucometer using blood taken from cut tail tips. Values are means ± SE of 5 mice. *P < 0.05 vs. control mice.