The relationship between N-terminal prosomatostatin, all-cause and cardiovascular mortality in patients with type 2 diabetes mellitus (ZODIAC-35)

Table 2 Hazard ratio’s and additional value of baseline log ₂ NT-proSST concentrations in risk prediction compared to established cardiovascular risk markers

	Model 1	Model 2	Model 3	Model 4
All-cause mortality
Hazard ratio (95%CI)	2.80 (2.17-3.60)	1.48 (1.14-1.93)	1.09 (0.81-1.46)	NA
Harrel’s C (95% CI)	0.62 (0.59-0.65)	0.77 (0.75-0.80)	0.79 (0.77-0.82)	0.79 (0.77-0.82)
Grønnesby and Borgan test p-value	0.60	0.11	0.51	0.32
Cardiovascular mortality
Hazard ratio (95%CI)	3.86 (2.64-5.62)	2.21 (1.49-3.28)	1.07 (0.69-1.68)	NA
Harrel’s C (95% CI)	0.65 (0.60-0.70)	0.76 (0.72-0.80)	0.81 (0.77-0.84)	0.81 (0.77-0.84)
Grønnesby and Borgan test p-value	0.16	0.03	0.06	0.06

Model 1: crude.
Model 2: as model 1 and also adjusted for age and sex.
Model 3: as model 2 and also adjusted for duration of diabetes, smoking (yes/no), macrovascular disease (yes/no), BMI, SBP, HbA_1c, log sCr, cholesterol-HDL ratio, albuminuria (yes/no) and NT-proSST.
Model 4: model 3 without NT-proSST.
Abbreviations: BMI body mass index, CI confidence interval, HDL high-density lipoprotein, HR Hazard ratio, SBP systolic blood pressure, sCr serum creatinine.

ISSN: 1472-6823