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Table 2 Associations of CRP SNPs with diabetic retinopathy

From: C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes

SNP

Chr: position (Build 38)

Reference position*

Major/minor allele

Risk allele

Cases

Controls

OR (95% CI)

Pvalue (empiricalPvalue)

OR (95% CI)§

Pvalue§

(n = 593)

(n = 388)

     

Minor allele frequencies

Genotype count 11/12/22#

Minor allele frequencies

Genotype count 11/12/22#

    

rs2808629

1:159707006

+5283

A/G

G

0.452

171/297/115

0.389

141/180/57

1.296(1.076,1.561)

0.006(0.029)

1.261(1.022,1.555)

0.030

rs3093077

1:159709846

+2443

T/G

G

0.183

390/179/18

0.163

271/106/10

1.153(0.906,1.468)

0.248(0.612)

1.194(0.906,1.574)

0.209

rs1130864

1:159713301

3’ UTR

C/T

T

0.058

520/62/3

0.045

352/33/1

1.299(0.855,1.974)

0.219(0.667)

1.250(0.794,1.968)

0.335

rs2808634

1:159722783

−8194

C/T

T

0.160

420/155/17

0.151

281/97/10

1.070(0.833,1.375)

0.597(0.968)

1.056(0.804,1.386)

0.697

  1. P values < 0.05 are shown in bold.
  2. The additive model was used in the association analysis between genotype and DR.
  3. *position of SNP with reference to CRP.
  4. #11, major allele homozygotes; 12, heterozygotes; 2 2, minor allele homozygotes.
  5. §adjusted for duration of diabetes, HbA1c, systolic blood pressure, diastolic blood pressure, body mass index and sex.
  6. Empirical P values are based on 10,000 permutations.
  7. The OR with 95% CI shown is for the minor allele.