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Table 1 Basic parameters of rats in different experimental groups

From: Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats

Characteristics

CON

DM

DM + U50,488H

DM + vehicle

DM + nor-BNI

Baseline

Weight (g)

222.7 ± 10.17

225.2 ± 8.24

224.6 ± 8.87

220.2 ± 7.12

221.5 ± 9.60

Blood pressure (mmHg)

102.8 ± 6.56

104.7 ± 6.86

100.5 ± 5.50

103.9 ± 5.38

103.1 ± 5.66

Blood glucose (mmol/L)

7.9 ± 0.96

21.5 ± 2.67*

23.66 ± 2.65*

22.1 ± 3.57*

21.64 ± 2.46*

Plasma insulin (ng/ml)

2.29 ± 0.446

0.53 ± 0.077*

0.63 ± 0.125*

0.50 ± 0.061*

0.59 ± 0.116*

After 4 weeks of treatment

Weight (g)

419.7 ± 12.25

286.6 ± 14.61*

281.3 ± 17.44*

284.2 ± 12.45*

284.7 ± 16.66*

Blood pressure (mmHg)

103.6 ± 6.40

104.9 ± 6.14

102.3 ± 6.23

107.9 ± 5.41

104.5 ± 6.47

Blood glucose (mg/dL)

8.2 ± 0.94

22.3 ± 2.19*

21.4 ± 1.67*

22.8 ± 2.28*

22.7 ± 1.93*

Plasma insulin (ng/ml)

2.42 ± 0.466

0.51 ± 0.093*

0.58 ± 0.109*

0.50 ± 0.075*

0.56 ± 0.134*

  1. Legend: Data are mean ± SD (n = 15), *P < 0.05 vs. CON group.