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Figure 5 | BMC Endocrine Disorders

Figure 5

From: Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats

Figure 5

U50,488H suppressed DM-induced inflammatory response through NF-кB inhibition. ELISA analysis showed significant increases in serum levels of IL-6 (A), IL-8 (B), and sICAM-1 (C) in DM rats as compared with the CON group, and U50,488H treatment prevented these increases. (D) NF-κB p65 translocation was increased in DM rats as compared with the CON group, which was markedly attenuated by U50,488H treatment. *P < 0.05 vs. CON group, #P < 0.05 vs. DM group. (n = 5).

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BMC Endocrine Disorders

ISSN: 1472-6823

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