From: Safety and tolerability of sitagliptin in patients with type 2 diabetes: a pooled analysis
Adverse Experience | Sitagliptin 100 mg n (%) (N = 3415) | Non-Exposed n (%) (N = 2724) | Difference between Sitagliptin and Non-Exposed, % (95% CI)* |
---|---|---|---|
Vertigo | 24 (0.7) | 27 (1.0) | -0.3 (-0.8, 0.2) |
Abdominal Pain | 39 (1.1) | 33 (1.2) | -0.1 (-0.6, 0.5) |
Abdominal Pain Upper | 59 (1.7) | 33 (1.2) | 0.5 (-0.1, 1.1) |
Constipation | 79 (2.3) | 47 (1.7) | 0.6 (-0.1, 1.3) |
Diarrhea | 170 (5.0) | 144 (5.3) | -0.3 (-1.4, 0.8) |
Dyspepsia | 70 (2.0) | 40 (1.5) | 0.6 (-0.1, 1.2) |
Gastritis | 36 (1.1) | 30 (1.1) | -0.0 (-0.6, 0.5) |
Nausea | 85 (2.5) | 70 (2.6) | -0.1 (-0.9, 0.7) |
Toothache | 35 (1.0) | 33 (1.2) | -0.2 (-0.8, 0.3) |
Vomiting | 51 (1.5) | 34 (1.2) | 0.2 (-0.4, 0.8) |
Fatigue | 56 (1.6) | 53 (1.9) | -0.3 (-1.0, 0.4) |
Peripheral Edema | 62 (1.8) | 54 (2.0) | -0.2 (-0.9, 0.5) |
Bronchitis | 135 (4.0) | 83 (3.0) | 0.9 (-0.0, 1.8) |
Cellulitis | 28 (0.8) | 26 (1.0) | -0.1 (-0.6, 0.3) |
Gastroenteritis | 68 (2.0) | 48 (1.8) | 0.2 (-0.5, 0.9) |
Gastroenteritis Viral | 29 (0.8) | 27 (1.0) | -0.1 (-0.7, 0.3) |
Influenza | 145 (4.2) | 127 (4.7) | -0.4 (-1.5, 0.6) |
Nasopharyngitis | 244 (7.1) | 162 (5.9) | 1.2 (-0.1, 2.4) |
Pharyngitis | 52 (1.5) | 35 (1.3) | 0.2 (-0.4, 0.8) |
Sinusitis | 80 (2.3) | 60 (2.2) | 0.1 (-0.6, 0.9) |
Upper Respiratory Tract Infection | 265 (7.8) | 228 (8.4) | -0.6 (-2.0, 0.8) |
Urinary Tract Infection | 134 (3.9) | 100 (3.7) | 0.3 (-0.7, 1.2) |
Viral Infection | 36 (1.1) | 21 (0.8) | 0.3 (-0.2, 0.8) |
Blood Glucose Decreased | 13 (0.4) | 28 (1.0) | -0.6 (-1.1, -0.2) |
Blood Glucose Increased | 42 (1.2) | 51 (1.9) | -0.6 (-1.3, -0.0) |
Hyperglycemia | 34 (1.0) | 39 (1.4) | -0.4 (-1.0, 0.1) |
Hypoglycemia†| 117 (3.4) | 296 (10.9) | -7.4 (-8.8, -6.1) |
Arthralgia | 113 (3.3) | 92 (3.4) | -0.1 (-1.0, 0.8) |
Back Pain | 142 (4.2) | 108 (4.0) | 0.2 (-0.8, 1.2) |
Muscle Spasms | 38 (1.1) | 35 (1.3) | -0.2 (-0.8, 0.4) |
Musculoskeletal Pain | 54 (1.6) | 40 (1.5) | 0.1 (-0.5, 0.7) |
Myalgia | 38 (1.1) | 29 (1.1) | 0.0 (-0.5, 0.6) |
Neck Pain | 23 (0.7) | 26 (1.0) | -0.3 (-0.8, 0.2) |
Osteoarthritis | 58 (1.7) | 24 (0.9) | 0.8 (0.2, 1.4) |
Pain in Extremity | 84 (2.5) | 53 (1.9) | 0.5 (-0.2, 1.2) |
Dizziness | 86 (2.5) | 63 (2.3) | 0.2 (-0.6, 1.0) |
Headache | 169 (4.9) | 129 (4.7) | 0.2 (-0.9, 1.3) |
Hypoesthesia | 24 (0.7) | 31 (1.1) | -0.4 (-1.0, 0.0) |
Anxiety | 32 (0.9) | 27 (1.0) | -0.1 (-0.6, 0.4) |
Depression | 40 (1.2) | 29 (1.1) | 0.1 (-0.4, 0.6) |
Insomnia | 44 (1.3) | 35 (1.3) | 0.0 (-0.6, 0.6) |
Cough | 88 (2.6) | 73 (2.7) | -0.1 (-0.9, 0.7) |
Pharyngolaryngeal Pain | 44 (1.3) | 34 (1.2) | 0.0 (-0.5, 0.6) |
Rash | 35 (1.0) | 24 (0.9) | 0.1 (-0.4, 0.6) |
Hypertension | 110 (3.2) | 89 (3.3) | -0.0 (-1.0, 0.8) |