From: Safety and tolerability of sitagliptin in patients with type 2 diabetes: a pooled analysis
 | Sitagliptin 100 mg | Non-Exposed |
---|---|---|
RANDOMIZED, N | 3415 | 2724 |
 | n (%) | n (%) |
DISCONTINUED* | 1191 (34.9) | 1076 (39.5) |
Reason for discontinuation | Â | Â |
   Clinical adverse experience | 119 (3.5) | 113 (4.1) |
   Laboratory adverse experience | 38 (1.1) | 22 (0.8) |
   Lack of efficacy†| 458 (13.4) | 381 (14.0) |
   Patient discontinued for other | 152 (4.5) | 176 (6.5) |
   Patient moved | 33 (1.0) | 19 (0.7) |
   Patient withdrew consent | 186 (5.4) | 203 (7.4) |
   Protocol specified discontinuation criteria | 48 (1.4) | 44 (1.6) |
   Protocol deviation | 58 (1.7) | 50 (1.8) |
   Lost to follow-up | 97 (2.8) | 65 (2.4) |
   Site terminated | 2 (0.1) | 3 (0.1) |