a) Reduced levels of both TSH and free T4.|
b) Thyrotroph T4 Sensitivity Index (TTSI) reduced below its reference interval.
|Reduced plasma protein binding||
a) Reduced relative ratios of bound and free hormone levels|
b) Reduced apparent dissociation constant of T3 at thyroxin binding globulin (K30)
a) Reduced level for free T3|
b) diminished T3/T4-ratio
c) reduced sum activity of peripheral 5'-Dejodinase (GD^)