Criterion | Definition |
---|---|
Thyrotropic insufficiency | a) Reduced levels of both TSH and free T4. b) Thyrotroph T4 Sensitivity Index (TTSI) reduced below its reference interval. |
Reduced plasma protein binding | a) Reduced relative ratios of bound and free hormone levels b) Reduced apparent dissociation constant of T3 at thyroxin binding globulin (K30) |
Reduced deiodation | a) Reduced level for free T3 b) diminished T3/T4-ratio c) reduced sum activity of peripheral 5'-Dejodinase (GD^) |