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Table 1 Proposed "HPD" classification

From: The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome

Facet

Possible values

Hypothalamic-pituitary dysfunction or adaptation ("H")

H0: Normal TSH secretion, adequate to T4 level

H1: Thyrotropic insufficiency

Impaired plasma protein binding ("P")

P0: Normal binding to plasma proteins

P1: Normal binding with reduced levels of plasma proteins

P2: reduced binding to proteins within normal levels

P3: reduced binding and reduced protein levels

Reduced deiodation ("D")

D0: Normal deiodation

D1: Reduced deiodation activity

  1. Example: H1P0D1: Thyrotropic insufficiency with reduced deiodation and normal protein binding.