TY - JOUR AU - Dietrich, Johannes W. AU - Stachon, Axel AU - Antic, Biljana AU - Klein, Harald H. AU - Hering, Steffen PY - 2008 DA - 2008/10/13 TI - The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome JO - BMC Endocrine Disorders SP - 13 VL - 8 IS - 1 AB - Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies. SN - 1472-6823 UR - https://doi.org/10.1186/1472-6823-8-13 DO - 10.1186/1472-6823-8-13 ID - Dietrich2008 ER -