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Table 1 Serum estradiol concentrations during a 24-hour profile in relation to pubertal stage in boys.

From: Twenty-four hours secretion pattern of serum estradiol in healthy prepubertal and pubertal boys as determined by a validated ultra-sensitive extraction RIA

Pubertal stage

N

Chronological age (yr)

Bone age TWII (yr)

17β-estradiol (pmol/L) Median (95% confidence interval)

    

0200 h

0600 h

1000 h

1400 h

1800 h

2200 h

Pre

16

9.9

(7.2 to 12.9)

9.1

(6.2 to 11.6)

<4

(<4 – 5)

<4

(<4 – 9)

<4

(<4 – 6)

<4

(<4 – 5)

<4

(<4)

<4

(<4 – 5)

Early

17

12.4

(9.8 to 13.8)

11.7

(9.7 to 13.1)

5

(5 – 7)

6

(5 – 9)

5

(<4 – 8)

6

(<4 – 8)

6

(<4 – 10)

4

(<4 – 9)

Mid

10

13.5

(11.2 to 14.1)

13.0

(10.7 to 13.5)

7e

(<4 – 12)

10bd

(6 – 17)

9e

(<4 – 13)

7e

(5 – 14)

7e

(5 – 12)

7

(5 – 15)

Late-1

10

15.2

(13.0 to 16.6)

15.2

(13.8 to 16.8)

20ace

(15 – 30)

27bcd

(21 – 39)

25bcd

(19 – 38)

21ace

(15 – 34)

18ae

(9 – 35)

15ae

(11 – 26)

Late-2

9

17.2

(16.6 to 18.6)

18.0

(15.4 to 18.0)

28ae

(21 – 36)

40cd

(24 – 58)

34cd

(27 – 63)

31ae

(17 – 46)

32

(22 – 42)

27ae

(16 – 36)

  1. P < 0.05 was considered to be significant
  2. aSignificantly lower than 1000
  3. bSignificantly higher than 1800
  4. cSignificantly higher than 2200
  5. dSignificantly higher than 0200
  6. eSignificantly lower than 0600