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Table 3 Significant association results between UCP1 and UCP2 SNPs and traits in populations from the IRAS Family Study

From: The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study

Trait

Population

Gene

SNP

Allele 1/Allele 2

Mean ± SE 1/1 (n)

Mean ± SE 1/2 (n)

Mean ± SE 2/2 (n)

P-value (General)

P-value (Dom)

P-Value (Add)

P-value (Rec)

AIRg a

Los Angeles

UCP1

A3826G

A/G

669.4 ± 86.3 (42)

954.2 ± 83.9 (93)

894.7 ± 65.1 (98)

0.017

0.006

0.366

0.786

AIRg a

San Luis Valley

UCP1

A3826G

A/G

718.4 ± 110.5 (74)

867.3 ± 81.9 (117)

855.9 ± 80.2 (23)

0.161

0.054

0.093

0.366

BMIb

San Antonio

UCP2

A55V

C/T

29.2 ± 0.82 (115)

28.7 ± 0.54 (210)

30.3 ± 0.71 (116)

0.040

0.968

0.220

0.018

Waistb

Los Angeles

UCP2

A55V

C/T

88.1 ± 0.60 (76)

87.1 ± 0.49 (139)

89.4 ± 0.67 (54)

0.045

0.440

0.510

0.065

WHRb

Los Angeles

UCP2

G-866A

G/A

0.82 ± 0.005 (77)

0.81 ± 0.005 (130)

0.83 ± 0.007 (51)

0.016

0.237

0.863

0.037

HDLa

San Antonio

UCP1

A3826G

A/G

40.2 ± 1.14 (164)

42.8 ± 1.10 (217)

44.9 ± 1.46 (66)

0.001

0.015

0.0004

0.006

  1. Empirical P-values are shown. aAdjusted for age, sex and BMI; badjusted for age and sex. General: General model; Dom: Dominant model; Add: Additive model; Rec: Recessive model. Bold: P < 0.05.