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Table 3 Significant association results between UCP1 and UCP2 SNPs and traits in populations from the IRAS Family Study

From: The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study

Trait Population Gene SNP Allele 1/Allele 2 Mean ± SE 1/1 (n) Mean ± SE 1/2 (n) Mean ± SE 2/2 (n) P-value (General) P-value (Dom) P-Value (Add) P-value (Rec)
AIRg a Los Angeles UCP1 A3826G A/G 669.4 ± 86.3 (42) 954.2 ± 83.9 (93) 894.7 ± 65.1 (98) 0.017 0.006 0.366 0.786
AIRg a San Luis Valley UCP1 A3826G A/G 718.4 ± 110.5 (74) 867.3 ± 81.9 (117) 855.9 ± 80.2 (23) 0.161 0.054 0.093 0.366
BMIb San Antonio UCP2 A55V C/T 29.2 ± 0.82 (115) 28.7 ± 0.54 (210) 30.3 ± 0.71 (116) 0.040 0.968 0.220 0.018
Waistb Los Angeles UCP2 A55V C/T 88.1 ± 0.60 (76) 87.1 ± 0.49 (139) 89.4 ± 0.67 (54) 0.045 0.440 0.510 0.065
WHRb Los Angeles UCP2 G-866A G/A 0.82 ± 0.005 (77) 0.81 ± 0.005 (130) 0.83 ± 0.007 (51) 0.016 0.237 0.863 0.037
HDLa San Antonio UCP1 A3826G A/G 40.2 ± 1.14 (164) 42.8 ± 1.10 (217) 44.9 ± 1.46 (66) 0.001 0.015 0.0004 0.006
  1. Empirical P-values are shown. aAdjusted for age, sex and BMI; badjusted for age and sex. General: General model; Dom: Dominant model; Add: Additive model; Rec: Recessive model. Bold: P < 0.05.