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Table 1 IRAS Family Study participant characteristics

From: The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study

  African American Hispanic
  Los Angeles San Luis Valley San Antonio
Families (n) 18 12 33
Family members per family (n) 4–51 4–39 6–30
Participantsa (n) 287 318 493
Female gender, % 56.5 52.2 60.0
Diabetes, % 11.6 12.8 17.7
Age, mean ± SD 43.8 ± 14.8 40.3 ± 14.0 43.6 ± 14.8
AIRg μU/mL ± SD 878.4 ± 768.2 808.1 ± 631.5 726.2 ± 620.1
SI, MINMOD, ± SD 1.75 ± 1.22 2.41 ± 2.00 1.95 ± 1.85
BMI, kg/m2 ± SD 28.8 ± 6.5 27.5 ± 5.6 30.1 ± 6.3
Waist, cm ± SD 89.3 ± 14.1 87.3 ± 13.2 92.9 ± 14.7
WHR, ratio ± SD 0.82 ± 0.08 0.85 ± 0.09 0.85 ± 0.08
HDL, mg/dL ± SD 48.3 ± 13.2 43.7 ± 12.4 42.4 ± 12.9
  1. aIncludes only individuals from the IRAS Family Study cohort with at least one UCP1 or UCP2 SNP genotype. Individuals in these families with type 2 diabetes have been excluded from AIRg and SI calculations. AIRg: Acute insulin response to glucose; SI: insulin sensitivity index; WHR: waist-to-hip ratio.