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Table 4 Analyses stratified according to genotype for the relationship between birth weight and risk factors for CVD and DM-2

From: An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36

  Wild type Variant carrier
Risk factor β 95% CI β 95% CI
BMI (kg/m2) 0.475 [-0.312; 1.262] 0.777 [-0.835; 2.338]
Fat mass (kg) -0.217 [-1.337; 0.904] -1.929* [-3.742; -0.116]
Fat free mass (kg) 0.780 [-0.212; 1.722] 0.473 [-0.897; 1.844]
Waist circumference (cm) -1.380 [-2.822; 0.061] 0.040 [-2.588; 2.668]
Waist-hip ratio 0.002 [-0.016; 0.021] 0.021 [-0.015; 0.057]
Systolic blood pressure (mmHg) -1.497 [-4.265; 1.272] -8.038* [0.014; -14.391]
Diastolic blood pressure (mmHg) -0.599 [-2.553; 1.355] -5.073** [-8.845; -1.301]
LDL cholesterol (mmol/l) -0.138 [-0.369; 0.093] -0.076 [-0.491; 0.339]
Resting heart rate (b/min) 2.540 [-0.865; 5.946] -1.995 [-8.277; 4.286]
Carotid intima-media thickness (mm)‡ 0.010 [-0.017; 0.036] 0.020 [-0.035; 0.075]
Glycated hemoglobin (%) -0.019 [-0.138; 0.101] -0.025 [-0.207; 0.157]
  1. Data is presented as regression coefficients (β) and their corresponding 95% confidence intervals (CI)
  2. CVD – cardiovascular disease; DM-2 – type 2 diabetes mellitus
  3. Models were adjusted for gender and adult body weight * p < 0.05 ** p < 0.01
  4. ‡ also adjusted for systolic and diastolic blood pressure