An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36

Table 4 Analyses stratified according to genotype for the relationship between birth weight and risk factors for CVD and DM-2

	Wild type		Variant carrier
Risk factor	β	95% CI	β	95% CI
BMI (kg/m²)	0.475	[-0.312; 1.262]	0.777	[-0.835; 2.338]
Fat mass (kg)	-0.217	[-1.337; 0.904]	-1.929*	[-3.742; -0.116]
Fat free mass (kg)	0.780	[-0.212; 1.722]	0.473	[-0.897; 1.844]
Waist circumference (cm)	-1.380	[-2.822; 0.061]	0.040	[-2.588; 2.668]
Waist-hip ratio	0.002	[-0.016; 0.021]	0.021	[-0.015; 0.057]
Systolic blood pressure (mmHg)	-1.497	[-4.265; 1.272]	-8.038*	[0.014; -14.391]
Diastolic blood pressure (mmHg)	-0.599	[-2.553; 1.355]	-5.073**	[-8.845; -1.301]
LDL cholesterol (mmol/l)	-0.138	[-0.369; 0.093]	-0.076	[-0.491; 0.339]
Resting heart rate (b/min)	2.540	[-0.865; 5.946]	-1.995	[-8.277; 4.286]
Carotid intima-media thickness (mm)‡	0.010	[-0.017; 0.036]	0.020	[-0.035; 0.075]
Glycated hemoglobin (%)	-0.019	[-0.138; 0.101]	-0.025	[-0.207; 0.157]

Data is presented as regression coefficients (β) and their corresponding 95% confidence intervals (CI)
CVD – cardiovascular disease; DM-2 – type 2 diabetes mellitus
Models were adjusted for gender and adult body weight * p < 0.05 ** p < 0.01
‡ also adjusted for systolic and diastolic blood pressure

ISSN: 1472-6823