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Table 3 Eight-hour studies with glucagon-like peptide 1. Effects of vehicle or 0.63 μg/kg subcutaneous GLP-1 and usual insulin at breakfast and lunch in paired studies in 9 volunteers with type 1 diabetes with no endogenous insulin secretion. Time-averaged incremental values (area under the curve divided by time) for plasma glucose through eight hours and for plasma pancreatic polypeptide from 0 to 30 min for both meals (HPP), and mean values for incremental plasma glucagon through 60 min for both meals, mean ± SE.

From: Glucagon-like peptide 1 improved glycemic control in type 1 diabetes

  Glucose mmol/l HPP pmol/l Glucagon ng/l
Vehicle 5.4 ± 0.8 37 ± 9.6 3.1 ± 1.7
GLP1 3.2 ± 0.9* 4.0± 3.1* -3.7 ± 2.5*
  1. *P < .05, paired t-tests for GLP-1 compared to vehicle