Factor | ||||||
---|---|---|---|---|---|---|
N with valid Followup times | 39,628 | 24,316 | 39,628 | |||
Time to diabetic ketoacidosis | Time to de novo diabetic ketoacidosisA | Time to hyperglycemic hyperosmolar syndromeB | ||||
P value | Adjusted HR (95% CI) | P value | Adjusted HR (95% CI) | P value | Adjusted HR (95% CI) | |
African American (all other races) | <0.0001 | 2.00 (1.63–2.48) | <0.0001 | 3.41 (1.99–5.84) | 4.87 (3.18–7.45) | |
Graft lossB (Absent) | <0.0001 | 1.63 (1.25–2.12) | ||||
Cadaveric Donor (living donor) | 0.027 | 2.14 (1.09–4.19) | ||||
Quartiles of Age (vs. >55 years) | ||||||
<33 | <0.0001 | 6.64 (4.59–9.61) | ||||
33–44 | <0.0001 | 4.75 (3.31–6.79) | 2.13 (1.34–3.37) | |||
45–55 | <0.0001 | 2.16 (1.47–3.17) | ||||
Diabetes at listing (vs. absent) | 10.06 (7.60–13.30) | Excluded | 0.0015 | 2.15 (1.34–3.46) | ||
BMI <21.6 vs. >28.3 kg/m2 | <0.0001 | 1.94 (1.44–2.62) | 2.33 (1.09–5.00) | |||
Recipient HCV Positive (Yes/No) | 0.01 | 2.16 (1.20–3.89) | ||||
Year of Transplant | <0.0001 | 1.49 (1.33–1.67) | 1.49 (1.25–1.78) | 0.001 | 1.73 (1.17–2.56) | |
Pretransplant dialysis (Yes/No) | <0.0001 | 2.11 (1.42–3.12) | ||||
Cause of ESRD (vs. all others) | ||||||
Diabetes | <0.0001 | 10.59 (8.52–13.18) | Excluded | |||
Maintenance Medications | ||||||
Tacrolimus (vs. Cyclosporine) | 0.019 | 2.20 (1.13–4.24) | ||||
Interaction Terms | ||||||
Tacrolimus*Cadaver Donor | 0.02 | 2.27 (1.17–4.41) | ||||
Tacrolimus*Year of Transplant | 0.03 | 0.70 (0.50–0.97) |