Figure 2
From: Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms
PLZF expression in a normal thyroid, an adenomatous lesion, a follicular adenoma, two papillary thyroid carcinomas with different degrees of capsular invasion and lymph node metastasis, and an anaplastic thyroid carcinoma representative of our study population. All images are × 400 magnification. IHC: immunohistochemical; N/C: nucleus/cytoplasm. (A) Normal thyroid showing nuclear staining (IHC score: N/C = 7/2). (B) Adenomatous lesion showing strong nuclear staining with intermediate cytoplasmic staining (IHC score: N/C = 7/3). (C) Follicular adenoma showing strong nuclear staining with intermediate cytoplasmic staining (IHC score: N/C = 7/4). (D) Papillary thyroid carcinoma without capsular invasion and lymph node metastasis showing faint cytoplasmic staining (IHC score: N/C = 0/3). (E) Papillary thyroid carcinoma with both capsular invasion and lymph node metastasis showing strong cytoplasmic staining (IHC score: N/C = 0/8). (F) Anaplastic thyroid carcinoma showing strong cytoplasmic staining (IHC score: N/C = 0/8).