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Table 3 Cases of hypoglycemia from NICTH secreting IGF-2 reported from 2008 till 2012

From: Hypoglycemia mediated by paraneoplastic production of Insulin like growth factor–2 from a malignant renal solitary fibrous tumor – clinical case and literature review

Reference

Age/sex

Tumor site

Tumor pathology

Hormone elevated

Management

[17]

28, male

Retroperitoneal pelvic region

Malignant solitary fibrous tumor

IGF-2

Surgical resection of turmor

[18]

68, male

Liver

Solitary fibrous tumor

Big IGF-2

Partial hepatic resection

[19]

59, male

Lungs and bones

Meningeal hemangiopericytoma

IGF-II (elevated IGF-2/IGF-1 levels)

Interferon alpha

[20]

75, male

Left pleural cavity

Pleural solitary fibrous tumor

Big IGF-2

Surgical resection

[21]

65, male

Retroperitoneal tumor

Retroperitoneal solitary fibrous tumor

IGF-2, Big IGF-2

Surgical resection

[22]

66, female

Right inferior thorax

Solitary fibrous tumor

IGF-2

Surgical resection

[23]

53, male

Liver

Metastatic hemangiopericytoma

Elevated IGF 2/IGF-1 ratio

Right hepatectomy

[24]

64, female

Right lower thorax

Malignant solitary fibrous tumor

Elevated IGFBP

Surgical resection, radiation post operatively

[25]

83, male

Retroperitoneum

Malignant solitary fibrous tumor

Big IGF-2

Surgical resection

[26]

43, male

Right posterior cranial fossa, metastatic lesions in bilateral kidney, right iliopsoas muscle, right iliac body, thoracic vertebra 10 body and segment IV of the liver

Meningeal hemangiopericytoma

Elevated IGF-2/IGF-1 ratio

Adriamycin

[27]

59, female

Right hemithorax

Solitary fibrous tumor

Elevated IGF-2/IGF-1 ratio

Surgical resection

[28]

67, male

Pelvis

Solitary fibrous tumor

Elevated IGF-2/IGF-1 ratio

Tumor embolization and radiotherapy

[29]

49, female

Right breast

Benign Phyllodes tumor

Big IGF-2

Mastectomy

[30]

49, female

Left breast

High grade Phyllodes sarcoma

Big IGF-2

Mastectomy

[31]

80, female

Uterus

Uterine leiomyoma

IGF-II, elevated IGF-2/IGF-1 ratio

Exploratory laparotomy

[32]

69, male

Spleen, lungs, liver

Hepatocellular carcinoma

Elevated IGF-2 mRNA expression

 

[33]

61, male

Liver

Poorly differentiated gastric adenocarcinoma

Big IGF-2, elevated IGF-2/IGF-1 ratio

Gastrectomy

[34]

27, female

Lung and liver

Ovarian germ cell tumor

Big IGF-2

Dexamethasone, recombinant Growth hormone

[35]

53, female

Right adrenal gland, liver

 

Elevated IGF-2/IGF-1 ratio

Phenoxybenzamine

[36]

45, Male

Pelvis and peritoneum

Desmoplastic small round cell tumor

Elvated IGF-2 and IGF-2/IGF-1 ratio

chemotherapy

[37]

77, male

Liver and lungs

Hepatocellular carcinoma

Big IGF-2

chemotherapy

[38]

41, male

Pleura and posterior mediastinum

Solitary fibrous tumor

Big IGF-2

chemotherapy