Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies

Table 3 Association of metabolic syndrome related traits with thyroid function index in NHANES 2007–2010 participants*

Metabolic syndrome-related trait	All subjects				Males				Females
	Unadjusted		Adjusted^†		Unadjusted		Adjusted^††		Unadjusted		Adjusted^††
	β	p	β	P	β	p	β	p	β	P	β	P
Fasting glucose	0.09	0.08	0.01	0.78	0.15	<0.01	0.12	0.03	0.08	0.25	-0.02	0.76
Fasting insulin	0.05	0.13	0.06	0.07	0.12	<0.01	0.12	<0.01	-0.05	0.32	-0.03	0.56
HOMA-IR	0.07	0.02	0.06	0.04	0.15	<0.001	0.14	<0.001	-0.02	0.70	-0.03	0.52
HOMA-β	0.00	0.98	0.05	0.20	0.05	0.30	0.08	0.12	-0.09	0.16	0.00	0.98
WC	0.16	<0.0001	0.11	<0.001	0.21	<0.0001	0.20	<0.0001	0.13	<0.001	0.06	0.17
BMI	0.15	<0.0001	0.12	<0.001	0.20	<0.0001	0.20	<0.0001	0.11	<0.01	0.03	0.40
Total serum cholesterol	0.16	<0.0001	0.11	<0.01	0.13	<0.001	0.13	<0.001	0.20	<0.001	0.11	0.04
Serum triglycerides	0.13	<0.001	0.09	0.04	0.11	<0.01	0.10	0.02	0.20	0.001	0.12	0.07
Serum HDL cholesterol	0.00	0.98	0.00	0.85	-0.10	<0.001	-0.10	<0.001	0.05	0.09	0.04	0.11
Central obesity	0.32	<0.0001	0.22	<0.001	0.36	<0.0001	0.30	<0.0001	0.22	<0.01	0.05	0.58
Raised triglycerides	0.17	<0.01	0.01	0.90	0.09	0.17	-0.01	0.88	0.31	<0.01	0.13	0.20
Low HDL cholesterol	0.10	<0.01	0.04	0.12	0.14	0.02	0.10	0.08	0.02	0.69	-0.03	0.52
High blood pressure	0.31	<0.0001	0.08	0.16	0.32	<0.01	0.17	0.13	0.34	<0.001	0.02	0.83
Type 2 diabetes	0.30	<0.0001	0.04	0.55	0.24	0.02	0.00	0.98	0.33	0.001	0.07	0.47
Metabolic syndrome	0.32	<0.0001	0.16	0.05	0.29	0.01	0.19	0.11	0.29	0.06	0.09	0.62

*In this set, data on 2-hour glucose, 2-hour insulin and WHR were not available; ^†, adjusted for age, age², sex, age x sex interaction and age² x sex interaction; ^††, adjusted for age and age²; numbers in bold face indicate statistically significant associations after correcting for multiple testing.

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