Patients <65 y | Patients ≥65 y | |||||
---|---|---|---|---|---|---|
PBO | CANA 100 mg | CANA 300 mg | PBO | CANA 100 mg | CANA 300 mg | |
Triglycerides, n | 446 | 614 | 610 | 118 | 139 | 131 |
Mean ± SD baseline, mmol/L | 2.2 ± 1.4 | 2.1 ± 1.5 | 2.1 ± 1.5 | 1.8 ± 0.8 | 1.9 ± 1.1 | 1.7 ± 0.9 |
LS mean ± SE change | 0.01 ± 0.05 | -0.10 ± 0.04 | -0.23 ± 0.04 | -0.05 ± 0.05 | -0.14 ± 0.05 | -0.16 ± 0.05 |
Median (IQR) percent change | -1.6 | -6.0 | -9.3 | -3.2 | -7.4 | -9.2 |
(-22.1, 28.8) | (-26.4, 24.4) | (-28.6, 19.8) | (-20.4, 16.3) | (-21.9, 10.6) | (-25.8, 10.2) | |
LS mean ± SE percent change | 9.1 ± 2.2 | 3.7 ± 2.0 | 0.6 ± 2.0 | 2.6 ± 3.0 | -2.4 ± 2.8 | -2.5 ± 2.9 |
Difference versus PBO (95% CI) | -5.4 (-11.1, 0.3) | -8.5 (-14.2, -2.8) | -5.0 (-13.0, 3.1) | -5.1 (-13.3, 3.1) | ||
LDL-C, n | 444 | 609 | 601 | 118 | 137 | 129 |
Mean ± SD baseline, mmol/L | 2.9 ± 1.0 | 2.8 ± 0.9 | 2.7 ± 0.9 | 2.7 ± 1.0 | 2.6 ± 0.9 | 2.7 ± 1.0 |
LS mean ± SE change | -0.05 ± 0.03 | 0.06 ± 0.03 | 0.17 ± 0.03 | -0.07 ± 0.06 | 0.04 ± 0.05 | 0.07 ± 0.06 |
Median (IQR) percent change | -2.3 | 2.0 | 6.5 | -1.5 | 1.9 | 2.0 |
(-16.9, 11.3) | (-10.7, 19.4) | (-7.8, 23.9) | (-9.8, 12.2) | (-7.1, 15.5) | (-10.5, 17.9) | |
LS mean ± SE percent change | 1.5 ± 1.4 | 6.3 ± 1.2 | 9.8 ± 1.2 | 0.7 ± 2.1 | 3.5 ± 1.9 | 6.8 ± 2.0 |
Difference versus PBO (95% CI) | 4.8 (1.2, 8.4) | 8.3 (4.7, 11.9) | 2.7 (-2.9, 8.4) | 6.1 (0.4, 11.8) | ||
HDL-C, n | 446 | 612 | 606 | 118 | 138 | 129 |
Mean ± SD baseline, mmol/L | 1.2 ± 0.3 | 1.2 ± 0.3 | 1.2 ± 0.3 | 1.2 ± 0.3 | 1.3 ± 0.3 | 1.3 ± 0.3 |
LS mean ± SE change | 0.03 ± 0.01 | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.03 ± 0.02 | 0.12 ± 0.02 | 0.12 ± 0.02 |
Median (IQR) percent change | 3.2 | 7.3 | 9.5 | 3.9 | 9.2 | 9.7 |
(-6.0, 13.6) | (-2.6, 19.6) | (-0.7, 20.0) | (-4.7, 11.8) | (0.0, 17.6) | (-0.8, 21.2) | |
LS mean ± SE percent change | 4.0 ± 0.8 | 9.2 ± 0.7 | 10.2 ± 0.7 | 3.6 ± 1.4 | 9.8 ± 1.3 | 10.8 ± 1.4 |
Difference versus PBO (95% CI) | 5.2 (3.1, 7.3) | 6.1 (4.1, 8.2) | 6.2 (2.4, 9.9) | 7.2 (3.4, 11.0) | ||
LDL-C/HDL-C, n | 444 | 609 | 601 | 118 | 137 | 129 |
Mean ± SD baseline, mol/mol | 2.6 ± 1.1 | 2.5 ± 1.0 | 2.4 ± 0.9 | 2.3 ± 1.0 | 2.2 ± 0.9 | 2.2 ± 0.8 |
LS mean ± SE change | -0.13 ± 0.03 | -0.12 ± 0.03 | -0.07 ± 0.03 | -0.10 ± 0.05 | -0.15 ± 0.05 | -0.11 ± 0.05 |
Median (IQR) percent change | -6.8 | -5.4 | -1.5 | -4.4 | -3.3 | -7.3 |
(-19.3, 9.3) | (-19.0, 10.9) | (-16.3, 14.1) | (-19.8, 12.8) | (-17.4, 7.8) | (-21.9, 11.8) | |
LS mean ± SE percent change | -0.5 ± 1.4 | -0.7 ± 1.2 | 1.3 ± 1.2 | -1.4 ± 2.3 | -4.2 ± 2.2 | -1.2 ± 2.3 |
Difference versus PBO (95% CI) | -0.2 (-3.8, 3.4) | 1.8 (-1.8, 5.4) | -2.8 (-9.1, 3.4) | 0.2 (-6.2, 6.5) | ||
Non–HDL-C, n | 446 | 609 | 602 | 117 | 138 | 127 |
Mean ± SD baseline, mmol/L | 3.9 ± 1.1 | 3.8 ± 1.1 | 3.6 ± 1.0 | 3.5 ± 1.2 | 3.5 ± 1.1 | 3.5 ± 1.1 |
LS mean ± SE change | -0.04 ± 0.04 | 0.00 ± 0.03 | 0.10 ± 0.03 | -0.09 ± 0.07 | -0.02 ± 0.06 | -0.02 ± 0.06 |
Median (IQR) percent change | -2.3 | -0.7 | 2.4 | -2.6 | 0.0 | 0.0 |
(-13.6, 9.7) | (-10.2, 13.1) | (-8.6, 14.9) | (-10.6, 9.5) | (-6.3, 11.5) | (-12.6, 13.5) | |
LS mean ± SE percent change | 1.1 ± 1.0 | 2.6 ± 0.9 | 4.7 ± 0.9 | -0.5 ± 1.8 | 0.8 ± 1.7 | 2.8 ± 1.8 |
Difference versus PBO (95% CI) | 1.4 (-1.3, 4.1) | 3.6 (0.8, 6.3) | 1.3 (-3.6, 6.2) | 3.3 (-1.7, 8.3) |