Levels of brain natriuretic peptide are associated with peripheral arterial disease in subjects with type-2 diabetes mellitus

Table 2 Logistic regression analysis examining BNP quartiles in relation to prevalence of PAD in diabetic patients (n = 507)

Group	Quartiles of BNP
Group	OR	95% CI	p
Model 1 with quartile group as categorical variables
Group 1 (lowest values)	Reference
Group 2	1.13	0.97–1.31	0.062
Group 3	1.19	1.11–1.34	0.018
Group 4 (highest values)	1.31	1.21–1.59	0.011
P for trend	1.22	1.17–1.41	0.015
1 SD change in BNP included as continuous variable	1.21	1.19–1.45	0.012
Model 2 with quartile group as categorical variables
Group 1 (lowest values)	Reference
Group 2	1.07	0.95–1.21	0.081
Group 3	1.15	1.02–1.31	0.047
Group 4 (highest values)	1.25	1.10–1.43	0.032
P for trend	1.18	1.11–1.35	0.039
1 SD change in BNP included as continuous variable	1.16	1.04–1.34	0.021

Model 1 was adjusted for age and sex.
Model 2 was adjusted for age, sex, BMI, BP, uric acid, UACR, smoking, TG, LDL-C, HDL-C, duration of diabetes and HbA1c.
BNP levels were as follows median (25–75% interquartile range): quartile 1, 24.0 (4.5 –25.0) pg/ml; quartile 2, 43.0 (26.5 –75.0) pg/ml; quartile 3, 86.0 (76.5 –100) pg/ml; quartile 4, 146.2 (100.5 –529) pg/ml.

ISSN: 1472-6823