Table 1 Changes in hormone levels and clinical parameters
At diagnosis of hyperglycemia | At 24 hours | At 72 hours | P | ||||
|---|---|---|---|---|---|---|---|
Median | (IQR) | Median | (IQR) | Median | (IQR) | ||
Blood glucose, mg/dl | 249 | 217-315 | 153 | 112-194 | 125 | 109-166 | 0.0001 |
Insulinemia, mUI/L | 20 | 8.5-32.5 | 13 | 6.5-27.5 | 16 | 7-29 | 0.401 |
C-peptide, nmol/L | 2 | 0.8-2.7 | 1.6 | 1-2.6 | 2 | 0.9-3.9 | 0.903 |
β-cell function with C-peptide % | 49.2 | 30.8-91.3 | 96.3 | 78.4-139.8 | 135.9 | 95.2-187.8 | 0.001 |
Insulin sensitivity % with C-peptide | 13.2 | 10.3-32.2 | 21.9 | 11.9-33.0 | 20.6 | 11.9-38.7 | 0.085 |
Insulin resistance with C-peptide | 7.6 | 3.1 -9.6 | 4.5 | 3-8.4 | 4.9 | 2.7-8.3 | 0.081 |
Carbohydrate delivery, g/kg/day | 2 | 1.8 -4.4 | 4.8 | 1.9-8.5 | 7.3 | 4.8-9.2 | 0.001 |
TSH, mUI/L | 0.5 | 0.3-0.8 | 0.3 | 0.2-0.9 | 0.6 | 0.2-3.3 | 0.091 |
Free T4, ng/dL | 1 | 0.8-1.2 | 0.9 | 0.7-1.2 | 0.7 | 0.5-1.2 | 0.009 |
ACTH, ng/L | 21.5 | 12.8-41 | 21 | 12-33.5 | 20.8 | 11.6-34.4 | 0.410 |
Cortisol, μg/dL | 43.7 | 12.6-77.3 | 16.1 | 7.9 -30.1 | 15.5 | 8.9-34.9 | 0.001 |
GH, μg/L | 0.8 | 0.5-7.1 | 1.2 | 0.5-2.9 | 1.8 | 0.6-3.4 | 0.708 |
IGF1, μg/L | 26 | 25-89. | 25 | 25-54 | 25 | 25-48 | 0.132 |
PRIMS % | 15.6 | 5.7-42.5 | 13.2 | 4.2-33.6 | 7.5 | 1.4-29.2 | 0.349 |
PIM2 % | 2.7 | 1.4-11.8 | 3.4 | 2-18.9 | 5.4 | 0.5-25.2 | 0.397 |
PELOD % | 6.7 | 1-19.5 | 1.5 | 0.1-1.7 | 1.3 | 0-2.3 | 0.787 |
HR, bpm | 125 | 113.7-150.2 | 130 | 112.5-150 | 127.5 | 110-148.5 | 0.482 |
MAP, mmHg | 62 | 55.5-72.2 | 67 | 54.5-73.5 | 63 | 58-79.5 | 0.837 |