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Table 2 Association of SLC30A8 polymorphism with GADA negative diabetes among Malaysian subjects and ethnic groups

From: Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study

SLC30A8 SNPs

Control

GADA negative diabetes

Recessive

Dominant

Additive

OR (95% CI)

Freq.

11/12/22

Freq.

11/12/22

P-value

rs7002176 (A  > T )

Combined*

0.42

113/284/208

0.45

222/541/335

1.12(0.85–1.46) 0.43

1.17(0.93–1.47) 0.18

1.11(0.95–1.29) 0.19

Malay#

0.37

35/115/100

0.42

79/191/150

1.61(1.00–2.59) 0.05

1.16(0.80–1.67) 0.43

1.23(0.96–1.57) 0.11

Chinese#

0.48

46/98/55

0.47

56/160/75

0.70(0.43–1.14) 0.15

1.06(0.67–1.65) 0.81

0.89(0.67–1.19) 0.43

Indian#

0.43

32/71/53

0.47

87/190/110

1.12(0.70–1.78) 0.65

1.32(0.88–1.99) 0.18

1.22(0.93–1.60) 0.15

rs1995222 ( A  < G)

Combined*

0.63

238/273/87

0.67

498/440/138

1.29(1.03–1.62) 0.02

1.17(0.85–1.60) 0.34

1.18(1.01–1.39) 0.039

Malay#

0.60

88/116/40

0.64

167/189/54

1.22(0.85–1.77) 0.28

1.55(0.93–2.58) 0.10

1.24(0.95–1.61) 0.11

Chinese#

0.54

57/97/43

0.54

87/133/66

1.16(0.75–1.79) 0.51

0.97(0.60–1.56) 0.89

1.05(0.80–1.38) 0.73

Indian#

0.78

93/60/4

0.80

244/118/18

1.26(0.85–1.87) 0.25

0.27(0.06–1.22) 0.09

1.11(0.79–1.56) 0.53

rs13266634 (C  > T )

Combined*

0.60

223/284/105

0.65

506/415/181

1.45(1.16–1.81) 0.001

0.99(0.75–1.32) 0.96

1.18(1.01–1.37) 0.03

Malay#

0.58

84/127/42

0.60

158/192/73

1.16(0.80–1.66) 0.44

0.85(0.53–1.35) 0.49

1.02(0.79–1.30) 0.90

Chinese#

0.50

56/90/56

0.49

85/115/91

1.14(0.74–1.76) 0.55

0.93(0.61–1.44) 0.76

1.03(0.79–1.33) 0.84

Indian#

0.74

83/67/7

0.82

263/108/17

1.93(1.31–2.85) 0.001

0.81(0.31–2.14) 0.68

1.58(1.14–2.17) 0.006

  1. Risk allele frequency (Freq.) and genotype counts in individuals with GADA negative diabetes and control subjects. 11, homozygous of major allele; 12, heterozygous; 22, homozygous of minor allele. GADA, glutamic acid decarboxylase antibodies. Risk allele is denoted in boldface. Bolded values are significant. *Controlled for age, race, gender and BMI. #Controlled for age, gender and BMI. The outliers (studentized residual is greater than 2.0 or less than −2.0) were excluded.