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Table 3 Performance of HOMA-IR values in the classification of cardio metabolic risk (both ATPIII MetS and IDF MetS definition), influence of age and gender

From: Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study

  

ROC coefficients*

P value

AUC (95% CI)

A

Males

   

IDF MetS

   

• Age

0.0102

0.1665

0.69 (0.65, 0.74)

• Intercept

−1.1411

0.0048

 

ATPIII Mets

   

• Age

0.0117

0.1897

0.72 (0.67, 0.77)

• Intercept

−1.2976

0.0089

 
 

Females **

   
 

IDF MetS

   

• Age 30 yr

  

0.82 (0.71, 0.90)

• Age 50 yr

 

<0.001

0.77 (0.68, 0.82)

• Age 70 yr

  

0.58 (0.48, 0.68)

 

ATPIII MetS

   

• Age 30 yr

  

0.83 (0.71, 0.91)

• Age 50 yr

 

0.012

0.80 (0.71, 0.85)

• Age 70 yr

  

0.61 (0.52, 0.70)

B

Males

   

IDF MetS

   

• Age

−0.0113

0.8998

0.68 (0.59, 0.78)

• Intercept

0.1406

0.5160

 

ATPIII MetS

   

• Age

−0.0029

0.8595

0.72 (0.62, 0.81)

• Intercept

−0.4692

0.6515

 
 

Females

   
 

IDF MetS

   

• Age

−0.0010

0.9656

0.54 (0.44, 0.64)

• Intercept

0.0173

0.9914

 
 

ATPIII MetS

   

• Age

−0.0010

0.9656

0.54 (0.44, 0.64)

 

• Intercept

0.0173

0.9914

 
  1. Areas under the ROC curves for non-diabetic (A) and diabetic (B) adults (n = 2459).
  2. AUC (95% CI), area under the ROC curve (95% Confidence Interval). *ROC regression models incorporating age as covariate. **The AUC was estimated for three ages (30, 50, and 70 years) to illustrate the performance of HOMA-IR. HOMA-IR, homeostasis model assessment of IR; ATPIII, Third Adult Treatment Panel; IDF, International Diabetes Federation; MetS, Metabolic Syndrome.
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BMC Endocrine Disorders

ISSN: 1472-6823

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