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Table 1 Clinical and biological characteristics of study patients by IR

From: Insulin resistance and adipokines serum levels in a caucasian cohort of hiv-positive patients undergoing antiretroviral therapy: a cross sectional study

Characteristics Total patients Patients without IR (Group 1) Patients with IR (Group 2) P
N 89 30 (33.7) 59 (66.3)  
Age (years) a 28 (22) 20.5 (13) 33 (25) 0.12
Males 51 (57.3) 14 (46.7) 37 (62.7) 0.14
BMI (kg/m 2 ) 23.6 ± 3.9 22.6 ± 3.8 24.2 ± 3.8 0.3
Fasting glucose (mg/dl) 85.7 ± 13.7 82.3 ± 8.6 87.2 ± 15 0.12
Haemoglobin A1c (%) 4.85 ± 0.39 4.82 ± 0.25 4.86 ± 0.43 0.66
Hypertension b 23 (25.8) 8 (26.7) 15 (25.4) 1.00
CD4 Tcell (cells/mm 3 ) a 440 (402) 525 (470) 428 (370) 0.38
Patients with undetectable HIV viral load 65 (73) 20 (66.7) 45 (76.3) 0.33
Time on antiretroviral therapy (months) a 72.5 (95) 80 (120) 70.5 (95) 0.21
Time from HIV diagnosis (months) a 80.5 (83) 92 (96) 76 (64) 0.36
Current Protease Inhibitor treatment 65 (73) 23 (76.7) 42 (71.2) 0.58
Total cholesterol (mg/dl) 192 ± 38.4 181.9 ± 33 199.6 ± 39.9 0.04*
HDL cholesterol (mg/dl) 43.9 ± 12.4 42.9 ± 10.5 44.3 ± 13.3 0.53
LDL cholesterol (mg/dl) 111.87 ± 35.4 107.3 ± 32.7 114.1± 36.8 0.39
Triglycerides (mg/dl) a 166 (129) 151.5 (79) 181 (169) 0.04*
Dyslipidemia c 71 (79.8) 24 (80) 47 (79.7) 1.00
Hypertriglyceridemia d 54 (60.7) 16 (53.3) 38 (64.4) 0.36
Adiponectin (μg/mL) a 10.2 (12.5) 16 (28.8) 9.4 (10.7) 0.00*
Leptin (ng/mL) a 1.4 (3.6) 1.8 (2.9) 1.3 (4.1) 0.53
Resistin (ng/mL) a 5.5 (3.6) 5.2 (5.1) 5.7 (3.4) 0.63
TNF alfa (pg/mL) a 10.3 (15.1) 11.9 (16.2) 9.7 (15) 0.62
IL-6 (pg/mL) a 26.5 (10.3) 26.6 (23.1) 26.5 (8.4) 0.52
  1. Data are shown as mean ± SD or number (percent).
  2. a Results presented as median (interquartile range).
  3. b Hypertension defined as blood pressure ≥130/≥85 mm Hg or antihypertensive medication.
  4. c Dyslipidemia defined as elevation of one of the following: total cholesterol, LDL cholesterol, triglyceride serum concentrations or a decrease of HDL cholesterol.
  5. d Hypertriglyceridemia defined as serum triglycerides ≥150 mg/dl.
  6. * p<0.05 Group 1 vs. Group 2.
  7. p values based on t-test for equality of means or Mann–Whitney test for continuous variables, Chi-square or Fisher’s exact test for categorical variables.