Table 3 Genotype distributions of the four SNPs of IL21 gene and two SNPs of IL-21R gene
SNP ID | Geno-type | Control | GD | HT | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Count (frequency%) | Count (frequency %) | Additive P value | Dominant P value | Recessive P value | Count (frequency %) | Additive P value | Dominant P value (OR,95% CI) | Recessive P value (OR,95% CI) | ||
IL-21 | ||||||||||
rs907715 | GG | 69(29.6) | 121(30.9) | 0.845 | 0.726 | 0.746 | 70(31.3) | 0.334 | 0.568 | 0.264 |
GA | 120(51.5) | 192(49.1) | 98(43.8) | |||||||
AA | 44(18.9) | 78(19.9) | 56(25.0) | |||||||
rs4833837 | AA | 189(78.1) | 325(80.4) | 0.61 | 0.474 | 0.751 | 185(81.1) | 0.67 | 0.667 | 0.401 |
GA | 50(20.7) | 72(17.8) | 42(18.4) | |||||||
GG | 3(1.2) | 7(1.7) | 1(0.4) | |||||||
rs2221903 | AA | 176(73.6) | 324(80.2) | 0.063 | 0.053 | 0.061 | 185(81.1) | 0.07 | 0.132 | 0.021 (11.72,1.46-94.13) |
GA | 53(22.2) | 73(18.1) | 42(18.4) | |||||||
GG | 10(4.2) | 7(1.7) | 1(0.4) | |||||||
rs2055979 | GG | 92(38.5) | 143(36.4) | 0.808 | 0.595 | 0.857 | 91(41.6) | 0.731 | 0.455 | 0.572 |
GT | 108(45.2) | 188(47.8) | 96(43.8) | |||||||
TT | 39(16.3) | 62(15.8) | 32(14.6) | |||||||
IL-21R | ||||||||||
rs3093301 | CC | 64(26.4) | 111(27.5) | 0.571 | 0.762 | 0.391 | 81(35.7) | 0.079 | 0.023 (1.61, 1.07-2.42) | 0.896 |
TC | 128(52.9) | 197(48.9) | 100(44.1) | |||||||
TT | 50(20.7) | 95(23.6) | 46(20.3) | |||||||
rs2285452 | GG | 185(77.7) | 318(78.7) | 0.823 | 0.707 | 0.999 | 193(85.0) | 0.051 | 0.031 (1.71, 1.05-2.80) | 0.435 |
GA | 52(21.8) | 83(20.5) | 32(14.1) | |||||||
AA | 1(0.4) | 3(0.7) | 2(0.9) | |||||||