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Table 2 Hormonal, metabolic, inflammatory and functional endothelial status in obese and non-obese PCOS women pre- and post-medical intervention. Data as means ± SEM

From: Ethinylestradiol30μg-drospirenone and metformin: could this combination improve endothelial dysfunction in polycystic ovary syndrome?

Variables

Obese PCOS

p-value

Non-Obese PCOS

p-value

 

Baseline

6 months

 

Baseline

6 months

 

BMI (kg/m2)

32.56 ± 1.13

29.71 ± 0.94

0.001

22.26 ± 0.55

21.72 ± 0.66

0.263

WHR

0.87 ± 0.01

0.86 ± 0.01

0.440

0.77 ± 0.01

0.75 ± 0.01

0.056

Glucose (mg/dl)

88.40 ± 1.62

84.60 ± 3.96

0.117

80.80 ± 1.91

80.80 ± 2.18

0.859

HOMA-IR

4.48 ± 0.42

3.29 ± 0.30

0.002

2.46 ± 0.17

2.10 ± 0.23

0.139

QUICKI

0.31 ± 0.004

0.32 ± 0.005

0.003

0.33 ± 0.003

0.34 ± 0.005

0.074

Insulin (μU/ml)

20.48 ± 1.79

15.85 ± 1.49

0.002

12.43 ± 0.85

10.57 ± 1.11

0.169

TC (mg/dl)

202 ± 20.65

220 ± 37.84

0.057

192 ± 29.24

208.20 ±20.77

0.047*

TG (mg/dl)

103.20 ± 35.41

135 ± 72.67

0.004

96.60 ± 33.48

111 ± 49.69

1.00

Total fat mass (%)

49.51 ± 3.30

47.43 ± 4.36

0.016*

35.94 ± 4.37

35.26 ± 3.71

0.508

Trunk fat mass (%)

51.82 ± 3.56

50.39 ± 4.00

0.173

35.86 ± 5.44

34.46 ± 5.00

0.203

Lean mass (kg)

40.54 ± 8.52

38.72 ± 8.27

0.006

36.75 ± 2.38

36.51 ± 2.56

0.721

TT (ng/ml)

0.86 ± 0.08

0.68 ± 0.03

0.009

0.80 ± 0.09

0.68 ± 0.01

0.241

FAI (%)

12.33 ± 2.64

4.56 ± 1.64

0.011*

5.74 ± 0.82

2.04 ± 0.41

0.007

F-G score

10.40 ± 1.42

8.67 ±1.21

0.007

8.70 ± 1.64

7.50 ± 1.45

0.016*

SHBG (nmol/l)

35.98 ± 6.10

144.03 ± 23.03

0.001

57.05 ± 8.59

155.06 ± 22.53

0.013*

SBP (mmHg)

109.67 ± 3.02

104.67 ±3.29

0.042*

101.00 ± 3.63

103.00 ± 3.59

0.732

DBP (mmHg)

74.67 ± 2.41

74.67 ± 1.91

0.886

65.00 ± 2.35

69.50 ± 2.93

0.098

HsCRP (mg/l)

6.10 ± 0.91

6.88 ± 1.14

0.307

3.40 ± 1.03

2.69 ± 0.95

0.646

FMD (%)

4.57 ± 1.31

8.58 ± 1.29

0.133

1.65 ± 1.44

5.55 ± 1.65

0.161

Baseline artery diameter (mm)

3.15 ± 0.11

3.06 ± 0.09

0.402

3.12 ± 0.08

2.99 ± 0.09

0.779

ET-1 (pg/ml)

2.36 ± 0.92

1.80 ± 0.42

0.198

1.71 ± 0.55

1.32 ± 0.20

0.508

  1. PCOS, polycystic ovary syndrome; BMI, body mass index; WHR, waist-to-hip ratio; HOMA-IR, homeostasis model assessment of insulin resistance; QUICKI, quantitative insulin sensitivity check index; TC, total cholesterol; TG, triglycerides; TT, total testosterone; FAI, free androgen index; SHBG, sex-hormone binding protein; SBP, systolic blood pressure; DBP, diastolic blood pressure; FMD, flow-mediated dilatation; ET-1, endothelin-1;
  2. *P < 0.05; p < 0.01.