Changes in the vitamin D endocrine system and bone turnover after oral vitamin D3 supplementation in healthy adults: results of a randomised trial

Table 2 Mean (SD) unadjusted serum levels of markers of the vitamin D endocrine system and bone turnover at baseline and follow-up according to type of supplement

Variable	n	Mean (SD) serum level at baseline	Mean (SD) serum level at follow-up	Mean (SD) change during intervention	p value ⁽²⁾
s-25(OH)D (nmol/l)
Overall	55	44.3 (23.6)	78.4 (24.5)	34.1 (13.1)	<0.001
Fish oil capsules	27	48.5 (24.8)	80.4 (25.0)	31.9 (15.3)	<0.001
Multivitamin tablets	28	40.3 (22.0)	76.5 (24.3)	36.2 (10.4)	<0.001
p value ⁽¹⁾		0.20	0.56	0.22
s-iPTH (pmol/l)
Overall	55	5.9 (2.6)	4.7 (2.1)	−1.2 (2.5)	0.001
Fish oil capsules	27	5.7 (2.6)	4.9 (2.5)	−0.9 (2.8)	0.13
Multivitamin tablets	28	6.0 (2.7)	4.5 (1.6)	−1.4 (2.2)	0.002
p value ⁽¹⁾		0.77	0.52	0.40
s-1,25(OH) ₂ D (pmol/l)
Overall	53	121 (41)	134 (38)	13 (48)	0.057
Fish oil capsules	27	128 (38)	136 (34)	8 (45)	0.37
Multivitamin tablets	26	113 (43)	131 (42)	18 (50)	0.09
p value ⁽¹⁾		0.20	0.64	0.46
s-TRACP (U/l)
Overall	54	2.65 (0.70)	3.03 (0.69)	0.38 (0.33)	<0.001
Fish oil capsules	27	2.59 (0.80)	3.01 (0.77)	0.43 (0.31)	<0.001
Multivitamin tablets	27	2.71 (0.61)	3.04 (0.60)	0.34 (0.36)	<0.001
p value ⁽¹⁾		0.53	0.87	0.32

⁽¹⁾ Differences between types of supplement are tested using t test.
⁽²⁾ Paired-samples t test for comparison of individual pre- and post-intervention concentration.

ISSN: 1472-6823