Severe hypoglycemia symptoms, antecedent behaviors, immediate consequences and association with glycemia medication usage: Secondary analysis of the ACCORD clinical trial data

Table 5 Unadjusted and adjusted HR of severe hypoglycemia by medication class - Intensive group participants ⁽¹⁾

Medication Use in Interval Antecedent to Ascertainment of Event Status	Unadjusted			Adjusted⁽²⁾
	HR	95% CI	P value	HR	95% CI	P value
Sulfonylurea	0.87	(0.73, 1.04)	0.12	1.06	(0.88, 1.28)	0.54
Biguanide	0.73	(0.59, 0.89)	<.0001	0.78	(0.63, 0.96)	0.02
TZDs	1.40	(1.15, 1.70)	<.0001	1.62	(1.33, 1.99)	<.0001
AGIs	1.05	(0.71, 1.54)	0.81	1.10	(0.74, 1.62)	0.64
Meglitinide	0.91	(0.74, 1.12)	0.37	1.10	(0.88, 1.38)	0.38
Incretin	0.97	(0.51, 1.82)	0.92	1.06	(0.56, 1.99)	0.86
Bolus Insulin	1.62	(1.35, 1.95)	<.0001	1.58	(1.26, 1.98)	<.0001
Basal Insulin	1.61	(1.30, 1.99)	<.0001	1.44	(1.13, 1.85)	<.0001
Pre-Mixed Insulin	1.41	(0.94, 2.13)	0.10	1.91	(1.25, 2.92)	<.0001

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