Table 1 Baseline Characteristics of Included Studies

Acarturk, 2004[13]

Prospective cohort

to investigate the relation

between age and gender differences in plasma TG and

CAD in patients with angiographically proven

CAD

patients

admitted for

diagnostic

coronary

angiography

due to chest

pain

54.9 +/-10.26

937

NR

Coronary artery

disease

Bansal, 2007[14]

Prospective cohort

To determine the association

of triglyceride levels (fasting

vs nonfasting) and risk of

future cardiovascular events.

healthy women

54.2 +/-

7.06

26,509

136.8

Months (median)

composite of

confirmed nonfatal

MI, nonfatal ischemic stroke, coronary revascularization, or death due to cardiovascular causes

Barrett-Connor, 1987[15]

Prospective cohort

To examine the independent

effect of triglyceride on the prediction of cardiovascular disease after the effects of cholesterol and other heart

disease risk factors have been accounted for

healthy fasting

men without

known CVD

57.7

1,589

144 months

N/A

Bass, 1993[16]

Prospective cohort

To further explore the relationships between lipid

and lipoprotein levels and

other conventional CVD risk factors and CVD death on women

women 30

years of age

and older

58.2 +/-

5.5

1,405

Mean 168 months

N/A

Bonaventure, 2010[17]

Prospective cohort

To find the association

pattern between serum TG

and incident intracerebral hemorrhage as compared

with coronary events and ischemic stroke

Population-

based, elderly participants

free from institutionalization were recruited from the electoral

rolls of three

French cities

74.03

years

8,393

mean of 5 years

MI, hospitalized

angina pectoris, acute coronary

syndrome, coronary endovascular

dilatation, coronary bypass, or death due to a coronary event

Carlson, 1988[18]

RCT

To obtain a pronounced

serum lipid lowering by combined use of clofibrate

and nicotinic acid in an effort

to reduce the risk of IHD

Survivors of

MI < 70 years

of age

58.9 + -0.4 males and 62.5 + -0.9 females

Control group (n = 276)

60 months

N/A

Chan, 2005[19]

Prospective cohort

To examine the lipid profiles

in Chinese type 2 diabetic patients and their relationship with anthropometric parameters, glycemic control and cardiovascular mortality.

Chinese

patients with

type 2 DM

54.0 +/-

14.0

517

Mean 55.2 +/-10.8 months

N/A

Chester, 1995[20]

Prospective cohort

To determine the standard clinical or angiographic variables or both present at initial angiography associated with the development of adverse coronary events in patients awaiting routine

PTCA

Patients

awaiting

routine

percutaneous transluminal

coronary

angioplasty

(PTCA)

57

215

Median 8 months

fatal or non-fatal MI, unstable angina or angiographic new total coronary occlusion

Czernichow, 2007[21]

Prospective cohort

To investigated the

relationship of baseline 'hypertriglyceridemic waist' (HTGW) status with CVD

risk in middle-aged French

men

middle-aged

French men,

included

diabetics

51.9 +/-

4.7

3,430

90 months

new-onset angina,

fatal and non-fatal MI or stroke, transient ischemic attack,

sudden death or intermittent claudication

Drexel, 2005[22]

Prospective cohort

To evaluate the

atherogenicity of lipids in coronary patients with

normal fasting glucose

(NFG), impaired fasting glucose (IFG), and type 2

DM

Caucasian

patients who

were referred

to coronary angiography

62.4 +/-

10.6

750

27.6 +/- 4.8 months

N/A

Eberly, 2003[23]

Prospective cohort

To determine whether HTG

is an independent risk factor

for coronary heart disease (CHD), and whether fasting

and nonfasting triglyceride (TG) levels are equally predictive

men at increased

risk but without clinical

evidence of

definite CHD

at baseline

46.3

2809

304.8 months

either a clinical MI or

a significant serial electrocardiogram change indicative of

MI

Egger, 1999[24]

Prospective cohort

To assess the influence of differential precision in the measurement of the

correlated variables total cholesterol and HDL cholesterol on estimates of

risk of IHD associated with

TG levels

Middle aged

men living in

the town of

Caerphilly,

South Wales,

UK

52.1 +/-

4.48

2,512

5 and 10 years after baseline

death from ischemic heart disease, clinical non-fatal MI, electrocardiographic

MI

Ellingsen, 2003[25]

Prospective cohort

to examine the effect of

group assignment on IHD mortality in subjects with normal or high fasting TG

healthy men

who had an

elevated serum

total

cholesterol concentration

or coronary

risk score

46 +/-3

1232

276 months

N/A

Gaziano, 1997[26]

Case controlled study

To examine the interrelationships of the

fasting TG level other lipid parameters and nonlipid risk factors with risk of MI.

Patients -

coronary care

and other

intensive care

units patients

(no history of

MI and angina pectoris) with

whom

symptoms of

MI had begun

24 h of

admission,

control -

residents of

home towns.

57.7 +/-

9.65

680

NR

N/A

Goldberg, 2009[27]

Prospective/

case controlled

To ascertain coronary artery disease outcomes and

predictive factors in patients with SLE and matched

healthy controls

prospectively

Patients with

systemic lupus erythematosus

(SLE) and

matched

healthy

controls

SLE cases 44.2 +/-12.2, controls 44.5 +/-

4.4

237 controls and 241 SLE cases

86.4 months

Defined as the occurrence of MI and/or angina pectoris due to atherosclerosis.

Habib, 2006[28]

Prospective cohort

To evaluate the association of serum TC and TG with

clinical outcomes in chronic peritoneal dialysis (PD)

patients.

Patients on

chronic

peritoneal

dialysis; only

in end-stage

renal disease

(ESRD) or

patients those

very ill

patients who

died rapidly

due to unrelated conditions.

57.2 +/

15.3

1,053

23 +/- 14 months

N/A

Haim, 1999[29]

Prospective cohort

To investigate the association between elevated blood triglyceride levels and subsequent mortality risk in patients with established coronary heart disease

(CHD)

patients with a diagnosis of CHD

59.76 +/- 6.96

11,546

61.2 months

N/A

Hoogeveen, 2001[30]

Case controlled study

To determine the effect of immigration to the USA ion plasma levels of lipoprotein a and other independent risk factors for CHD in Asian Indians

Asian Indians

and Asian

Indians living

in the USA

with and

without CHD

44.2 +/- 12.79

309

NR

Coronary heart disease - incidents not specifically defined

Jonsdottir, 2002[31]

Prospective cohort

To examine the relationship between the relative risk of baseline variables and

verified MI or coronary death

in individuals with no prior history of MI

male and

female from

Reykjavik and adjusted

communities

52.7 +/-

8.71

18,569

Mean 208.8 months

N/A

Lamarche, 1995[32]

Prospective cohort

To confirm the importance of both elevated plasma cholesterol and decreased

high density lipoprotein cholesterol levels as risk

factors for ischemic heart disease

men without

ischemic heart

disease

57.5

2,103

60 months

Effort angina pectoris, coronary

insufficiency, nonfatal MI, and coronary

death

Lloret Linares, 2008[33]

Retrospective cohort

to assess retrospectively the prevalence and the predictive factors of acute pancreatitis (AP)

Patients

referred by

their general practitioner or

general

hospital for

very high TG

levels.

47 +/-

10.7

129

NR

N/A

Lu, 2003[34]

Prospective cohort

To determine whether non-

HDL cholesterol, a measure

of total cholesterol minus

HDL cholesterol, is a

predictor of CVD in patients with DM

American

Indians with

DM

57.28 +/-

8

2,108

108 months

Coronary heart

disease,

MI, stroke, and other CVD

Malone, 2009[35]

Prospective cohort

This study evaluated cardiometabolic risk factors

and their relationship to prevalent diagnosis of acute

MI (AMI) and stroke.

People

continuously

receiving

health

insurance

benefits during

study

56.8 +/- 0.03

170,648

24 months

N/A

Mazza, 2005[36]

Prospective cohort

To evaluate whether TG level

is a risk factor for CHD in elderly people from general population, and to look for interactions between TG and other risk factors.

elderly people

from general population

CHD in elderly

people from

general

population

73.8 +/- 5

3,257

144 months

N/A

Mora, 2008[37]

Prospective cohort

To evaluate levels of lipids

and apolipoproteins after a typical meal and to determine whether fasting compared

with non-fasting alters the association of these lipids

and apolipoproteins with incident CVD.

Healthy

women, aged

> = 45 years,

who were free

of self-

reported CVD

or cancer at

study entry and with follow-up for

incident CVD.

54.7

26,330

136.8 months

Nonfatal MI, percutaneous

coronary

intervention,

coronary artery

bypass grafting, nonfatal stroke,

or

cardiovascular

death

Noda, 2010[38]

Case controlled study

To examine the prediction of coronary risk factors and evaluation of the predictive value for MI among Japanese middle-aged male workers.

Japanese male

workers

cases 50.4 + -5.3, controls 50.4 + -5.5 years

cases 204 and controls 408

36 months

N/A

Rubins, 1999[39]

RCT

To analyze the role of raising HDL cholesterol level and lowering triglyceride levels

to reduce the rate of coronary events in patients with

existing cardiovascular

disease

men with

coronary heart

disease with

absence of

serious

coexisting

conditions

64 + -7

1267 (placebo)

61.2 months

combined incidence of nonfatal MI or death from coronary heart disease

Samuelsson, 1994[40]

Prospective cohort

To analyze the importance of DM and HTG as potential

risk factors for CHD in

middle-aged, treated hypertensive men

middle aged

treated

hypertensive

men

52 +/- 2.3

686

180 months

Non-fatal MI, a fatal MI, a death certificate statement of coronary atherosclerosis as the cause of death

Schupf, 2005[41]

Prospective cohort

To investigate the

relationship between plasma lipids and risk of death from

all causes in non demented elderly

Community-

based sample

of Medicare

recipients

without

dementia

76.1

2,277

Mean 36 +/- 30 months

N/A

Sprecher, 2000[42]

Prospective cohort

To evaluate the predictive

value of serum triglyceride levels on mortality in post coronary artery bypass graft(CABG) diabetic

patients with subsequent analysis by sex

Diabetic post

CABG patients

at a large

metropolitan

hospital

63 +/- 9

1,172

84 months

N/A

Tanko, 2005[43]

Prospective cohort

To investigate the relative utility of enlarged waist combined with elevated TG (EWET) compared with the National Cholesterol

Education Program (MS-NCEP) criteria in estimating future risk of all-cause and cardiovascular mortality

Postmenopausal women

60.4 +/-

7.1

557

8.5 +/- 0.3 years

N/A

Tsai, 2008[44]

Retrospective cohort

To assess the effect of a

single and a combination of "pre-disease" risk factors of metabolic syndrome on the overall and cardiac mortality.

civil servants

and teachers

40 years and

older

52.4 + -

8.0

35,259

median follow-up of 15 years

N/A

Upmeier, 2009[45]

Prospective cohort

To determine whether high levels of serum total

cholesterol and low levels of HDL are related to increased mortality in elderly

Home

dwelling older

adults residents in Finland

70 years

877

144 months

N/A

Valdivielso, 2009[46]

Prospective cohort

To study the prevalence, risk factors and vascular disease associated with moderate and sever HTG in an active

working population

Active

working

population of

Spain

36 ± 10 years

594,701

NR

documented prior medical

diagnosis of heart disease, cerebrovascular

disease or peripheral arterial disease

Wier, 2003[47]

Prospective cohort

To investigate the

relationship between triglyceride and stroke

outcome

nondiabetic

patients

presenting to

acute stroke

unit

Median

70 years

1310

mean 1195 days

N/A