Association of Alanine Aminotransferase Levels (ALT) with the Hepatic Insulin Resistance Index (HIRI): a cross-sectional study

Table 4 Regression analysis of variables associated with the HIRI

Variable	β	Standardized β	T	p value
Model 1 (all subjects, n=324)
Age	−0.11	−0.13	−1.86	0.064
ALT	0.07	0.17	2.50	0.013
HDL-C	−0.07	−0.05	−0.67	0.501
TG	0.009	0.114	1.60	0.111
WC	0.17	0.22	2.98	0.003
Model 2 (Subjects without metabolic abnormalities, n=113)
Age	−0.05	−0.06	−0.57	0.569
ALT	0.005	0.009	0.08	0.933
HDL-C	−0.04	−0.05	−0.49	0.623
TG	0.013	0.065	0.61	0.541
WC	0.17	0.25	2.40	0.018
Model 3 (Subjects with metabolic syndrome, n=179)
Age	−0.11	−0.13	−1.86	0.064
ALT	0.07	0.17	2.50	0.013
HDL-C	−0.07	−0.05	−0.67	0.501
TG	0.009	0.11	1.60	0.111
WC	0.17	0.22	2.98	0.003
Model 4 (Subjects with impaired fasting glucose, n=85)
Age	−0.07	−0.08	−0.72	0.470
ALT	0.107	0.26	2.31	0.023
HDL-C	−0.05	−0.05	−0.39	0.697
TG	0.01	0.08	0.68	0.496
WC	0.08	0.11	0.97	0.334
Model 5 (Subjects with impaired glucose tolerance, n=91)
Age	−0.17	−0.24	−2.41	0.018
ALT	0.09	0.28	2.78	0.007
HDL-C	0.02	0.02	0.201	0.841
TG	0.008	0.06	0.66	0.507
WC	0.14	0.22	2.18	0.032
Model 6 (Subjects with type 2 diabetes, n=23)
Age	0.07	0.09	0.52	0.611
ALT	0.31	0.68	3.61	0.003
HDL-C	0.10	0.09	0.42	0.679
TG	0.01	0.15	0.75	0.463
WC	−0.09	−0.11	−0.48	0.636

Parameters of model 1: Constant: 23.6, F = 7.20; r² = 0.17, p = <0.001.
Parameters of model 2: Constant: 17.72, F = 1.43; r² = 0.07, p = 0.221.
Parameters of model 3: Constant: 23.6, F = 7.20; r² = 0.17, p < 0.001.
Parameters of model 4: Constant: 27.7, F = 2.81; r² = 0.16, p = 0.02.
Parameters of model 5: Constant: 23.0, F = 5.94; r² = 0.28, p = 0.001.
Parameters of model 6: Constant: 21.0, F = 3.26; r² = 0.53, p = 0.037.
ALT = alanine aminotransferase, HDL-C = high density lipoprotein cholesterol, TG = Triglycerides, WC = waist circumference, HIRI = Hepatic Insulin Resistance Index.

ISSN: 1472-6823