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Table 3 Partial correlations of the HIRI with clinical and biochemical parameters

From: Association of Alanine Aminotransferase Levels (ALT) with the Hepatic Insulin Resistance Index (HIRI): a cross-sectional study

 

HIRI (adjusted for sex, age and BMI)

 

All subjects (n = 324)

Without metabolic abnormalities (n = 113)

Metabolic syndrome (n = 179)

IFG (n = 85)

IGT (n = 91)

T2DM (n = 23)

Variable

r

r

r

r

r

r

Weight

0.07

−0.17

0.13

0.09

0.24b

0.13

WC

0.15b

0.04

0.16b

0.12

0.20

−0.31

SBP

0.09

0.05

0.05

−0.15

0.02

−0.13

DBP

0.08

0.09

0.01

−0.21

0.03

−0.02

ALT

0.20a

0.03

0.22b

0.33a

0.37b

0.72a

AST

0.22a

0.12

0.19b

0.26b

0.38a

0.51b

Cholesterol

0.01

−0.17

0.001

0.02

0.10

0.19

Triglycerides

0.19a

0.05

0.13

0.19

0.16

0.31

HDL-C

-0.15

-0.08

-0.08

-0.16

-0.05

0.21

Body fat

0.07

-0.03

0.10

0.01

0.19

0.09

Glucose

0.12b

0.16

0.03

0.01

0.09

0.29

Insulin

0.54a

0.63a

0.51a

0.56a

0.69a

0.81a

HOMA2-IR

0.53a

0.63a

0.51a

0.56a

0.69a

0.81a

ISI Matsuda

-0.59a

-0.60

-0.57a

0.61a

0.69a

-0.84a

  1. P Values obtained of individual comparison using Spearman (normally distributed variable) or Pearson (skewed distribution variables) bivariate correlation tests: a = p < 0.001, b = p < 0.05. BMI = body mass index, WC = waist circumference, SBP = systolic blood pressure, DBP = diastolic blood pressure, ALT = alanine aminotransferase, AST = aspartate aminotransferase, HDL-C = high density lipoprotein cholesterol, HOMA2-IR = Homeostasis Model Assessment Insulin Resistance 2, ISI = Insulin Sensitivity Index, and HIRI = Hepatic Insulin Resistance Index. The total number of subjects is different from 324, because, 40% (n = 73) of subjects with MetS have IFG, 36% (n = 66) of subjects with MetS have IGT, and 11% of subjects (n = 20) of subjects with MetS have DM2.