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Table 2 Characteristics of the subjects studied stratified by quartiles of HIRI (n = 324)

From: Association of Alanine Aminotransferase Levels (ALT) with the Hepatic Insulin Resistance Index (HIRI): a cross-sectional study

Variables

HIRI value (quartiles)

 

<28.2 (n = 79)

28.2-35.7 (n = 82)

35.7-43.2 (n = 82)

≥43.2 (n = 81)

p value

Age (years)

41.3 ± 15.5

43.5 ± 14.7

40.0 ± 12.7

36.9 ± 13.9

0.03

Sex male (n, %)

28 (35.4)

29 (35.3)

35 (42.6)

30 (37.0)

0.74

Weight (kg)

75.4 ± 15.3

80.3 ± 18.4

90.8 ± 20.0

92.4 ± 21.8

<0.001

BMI (kg/m2)

28.5 ± 6.2

30.5 ± 6.4

34.5 ± 8.9

34.8 ± 7.4

<0.001

WC (cm)

95.1 ± 15.1

101.3 ± 15.0

108.8 ± 15.2

110.1 ± 17.0

<0.001

Male

96.0 ± 10.9

103.2 ± 12.6

108.4 ± 14.7

111.9 ± 16.0

<0.001

Female

94.6 ± 17.0

100.3 ± 16.2

109.0 ± 15.7

109.0 ± 17.7

<0.001

SBP (mmHg)

113.9 ± 14.1

121.0 ± 16.8

118.2 ± 14.4

117.4 ± 12.8

0.007

DBP (mmHg)

74.1 ± 10.9

77.6 ± 8.0

79.7 ± 9.7

77.4 ± 10.2

0.001

ALT (IU/L)

21.0 (15.0-29.0)

24.0 (19.7-34.0)

27.0 (21.0-46.0)

32.0 (24.0-68.0)

<0.001

Male

24.5 (15.5-40.2)

28.0 (23.0-36.0)

39.0 (26.0-61.0)

63.5 (31.0-93.0)

<0.001

Female

20.0 (15.0-26.0)

23.0 (19.0-30.0)

24.0 (20.0-37.0)

27.0 (22.0-40.0)

<0.001

AST (IU/L)

22.0 (19.0-29.0)

25.0 (21.0-31.0)

26.0 (21.0-37.0)

27.0 (22.5-45.5)

0.002

Male

24.5 (20.0-35.2)

28.0 (22.0-36.0)

29.0 (24.0-39.0)

38.5 (24.0-55.0)

0.026

Female

22.0 (19.0-27.0)

24.0 (20.5-29.0)

23.5 (19.0-34.2)

25.0 (21.0-36.0)

0.143

Cholesterol (mg/dL)

187.4 ± 39.5

190.2 ± 37.3

186.9 ± 36.5

191.0 ± 32.1

0.89

Triglycerides (mg/dL)

122.0 (81.5-166.0)

140.0 (95.0-204.2)

151.0 (114.2-204.0)

198.0 (148.5-348.5)

<0.001

HDL-C (mg/dL)

40.3 ± 12.5

40.5 ± 11.2

34.9 ± 8.1

35.1 ± 10.1

<0.001

Male

32.8 ± 8.8

36.8 ± 11.5

36.1 ± 8.1

29.6 ± 6.4

0.03

Female

44.6 ± 12.3

42.4 ± 10.7

39.8 ± 10.9

36.8 ± 8.9

0.001

Body fat (%)

35.0 ± 9.5

37.0 ± 8.7

39.8 ± 9.1

40.4 ± 8.0

<0.001

Male

27.0 ± 6.8

29.0 ± 5.6

33.0 ± 7.8

33.9 ± 6.4

<0.001

Female

39.4 ± 7.8

41.4 ± 6.8

45.0 ± 6.3

43.1 ± 7.4

<0.001

Glucose (mg/dL)

88.8 ± 12.9

94.2 ± 14.6

96.5 ± 12.7

95.1 ± 12.9

0.002

Insulin (μlU/mL)

6.5 (4.5-8.2)

8.2 (6.3-12.0)

13.1 (9.2-16.0)

17.6 (13.1-24.5)

<0.001

HOMA2-IR

0.8 (0.6-1.1)

1.1 (0.8-1.5)

1.7 (1.2-2.1)

2.3 (1.7-3.2)

<0.001

ISI Matsuda

6.9 (5.0-9.7)

4.6 (3.2-6.0)

2.9 (2.1-3.9)

2.0 (1.3-2.6)

<0.001

HIRI

23.4 ± 3.0

31.7 ± 2.1

39.0 ± 2.1

53.3 ± 9.5

<0.001

  1. Data are expressed as mean ± SD, median (interquartil range), or frequency (%). Analyses were adjusted by gender. P values obtained of individual comparison using the Pearson chi square for frequency variables, one-way ANOVA (normally distributed variables) or Kruskall–Wallis (skewed distribution variables) test. BMI = body mass index, WC = waist circumference, SBP = systolic blood pressure, DBP = diastolic blood pressure, ALT = alanine aminotransferase, AST = aspartate aminotransferase, HDL-C = high density lipoprotein cholesterol, HOMA2-IR = Homeostasis Model Assessment Insulin Resistance 2, ISI = Insulin Sensitivity Index, and HIRI = Hepatic Insulin Resistance Index.
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BMC Endocrine Disorders

ISSN: 1472-6823

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