Table 4 TT, FT, and SHBG change from baseline after 3, 6, and 12 months of TRT, by baseline testosterone level quartiles
|  | Quartile 1 (<206 ng/dL) [<7.1 nmol/L] | Quartile 2 (206-256 ng/dL) [7.1-8.9 nmol/L] | Quartile 3 (257-330 ng/dL) [8.9-11.5 nmol/L] | Quartile 4 (≥331 ng/dL) [≥11.5 nmol/L] | p-Value, Differences Among Quartiles | |
|---|---|---|---|---|---|---|
| Â | Mean Value, Mean Change from Baseline (p-Value for Change from Baseline) | Mean Value | Mean Change From Baseline | |||
TT, ng/dL [nmol/L] | Â | Â | Â | Â | Â | Â |
   3 Months | 465 [16.1], +307 (<0.0001) | 466 [16.2], +234 (<0.0001) | 543 [18.8], +248 (0.0002) | 520 [18.0], +59 (0.3) | 0.7 | 0.02 |
   6 Months | 405 [14.1], +244 (<0.0001) | 379 [13.2], +148 (0.0007) | 425 [14.7], +135 (0.01) | 535 [18.6], -3.7 (0.9) | 0.09 | 0.002 |
   12 Months | 519 [18.0], +359 (<0.0001) | 456 [15.8], +225 (<0.0001) | 496 [17.2], +206 (0.0003) | 520 [18.0], +3.6 (0.9) | 0.7 | <0.0001 |
FT, pg/mL [pmol/L] | Â | Â | Â | Â | Â | Â |
   3 Months | 74 [256.8], +32 (0.1) | 93 [322.7], +19 (0.5) | 121 [419.9], +80 (0.0002) | 80 [277.6], +17 (0.03) | 0.3 | 0.1 |
   6 Months | 84 [291.5], +57 (0.0007) | 71 [246.4], +3.8 (0.8) | 82 [284.5], +45 (0.02) | 69 [239.4], +6.3 (0.7) | 0.8 | 0.06 |
   12 Months | 87 [301.9], +59 (0.0008) | 67 [232.5], +9.0 (0.7) | 56 [194.3], +18 (0.3) | 70 [242.9], +6.9 (0.7) | 0.5 | 0.1 |
SHBG, nmol/L | Â | Â | Â | Â | Â | Â |
   3 Months | 27.9, +2.83 (0.7) | 24.1, +0.1 (1.0) | 32.1, +1.52 (0.7) | 37.2, -1.66 (0.7) | 0.2 | 0.9 |
   6 Months | 25.6, -1.00 (0.9) | 25.7, +3.30 (0.6) | 26.5, -3.84 (0.4) | 38.9, -1.49 (0.7) | 0.06 | 0.8 |
   12 Months | 19.4, -6.50 (0.4) | 20.7, -1.45 (0.8) | 25.2, -6.72 (0.1) | 45.8, +5.75 (0.3) | 0.002 | 0.3 |