Skip to main content

Table 3 TT, FT, and SHBG change from baseline after 3, 6, and 12 months of TRT

From: Effect of 12 months of testosterone replacement therapy on metabolic syndrome components in hypogonadal men: data from the Testim Registry in the US (TRiUS)

 

MetS+

MetS-

p-Value, Differences

MetS+ vs MetS-

 

Mean Value, Mean Change from Baseline

(p-Value for Change from Baseline)

Mean Value

Mean Change From Baseline

TT, ng/dL [nmol/L]

    

3 Months

505 [17.5], +223 (<0.0001)

503 [17.5], +197 (<0.0001)

0.9

0.7

6 Months

398 [13.8], +172 (<0.0001)

455 [15.8], +123 (0.0002)

0.09

0.3

12 Months

487, +261 (<0.0001)

512, +190 (<0.0001)

0.5

0.2

FT, pg/mL [pmol/L]

    

3 Months

84.1 [291.8], +36.8 (0.02)

93.8 [325.5], +39.6 (0.003)

0.6

0.9

6 Months

77.4 [268.6], +55.8 (0.0001)

63.5 [220.3], +12.6 (0.2)

0.3

0.01

12 Months

77.5 [269.0], +49.7 (0.0007)

68.8 [238.7], +15.0 (0.2)

0.5

0.05

SHBG, nmol/L

    

3 Months

24.6, +1.67 (0.7)

31.7, -0.06 (1.0)

0.1

0.7

6 Months

24.3, -1.37 (0.7)

31.2, -1.64 (0.6)

0.1

1.0

12 Months

17.7, -6.93 (0.1)

33.4, -0.80 (0.8)

0.005

0.3

  1. Abbreviations: FT = free testosterone; SHBG = sex hormone-binding globulin; TT = total testosterone.