Table 1 Characteristics of 95 patients and separate case/control subjects
All Patients | Cases | Controls | P-values | |
|---|---|---|---|---|
TD | No TD | 95% CI | ||
N = 95 | N = 19 | N = 76 | ||
Demographic factors | ||||
Female gender - number (%) | 55 (57.9%) | 11 (57.9%) | 44 (57.9%) | NSS |
Mean age (years) ± SD | 47 ± 8 | 47 ± 8 | 48 ± 7 | NSS |
Weight (kg) ± SD | 69.7 ± 10.1 | 70.6 ± 8.5 | 69.8 ± 10.7 | NSS |
Hepatic factors | ||||
Cirrhosis - number (%) | 5 (5.3%) | 1 (5.3%) | 4 (5.3%) | NSS |
ALT (<45 U/L) ± SD | 54 ± 24 | 56 ± 26 | 53 ± 25 | NSS |
AST (1-30 U/L) ± SD | 39 ± 11 | 41 ± 12 | 38 ± 12 | NSS |
Virologic factors | ||||
Genotypes - number (%) | ||||
• 1 | 55 (58.0%) | 11 (58.0%) | 44 (58.0%) | NSS |
• 3 | 40 (42.0%) | 8 (42.0%) | 32 (42.0%) | NSS |
Viral Load | ||||
- At baseline (log IU/mL) ± SD | 6.44 ± 0.52 | 6.22 ± 0.56 | 6.64 ± 0.53 | NSS |
Treatment regimens - number (%) | ||||
IFN-α2a | 55 (57.9%) | 11 (57.9%) | 44 (57.9%) | NSS |
together with | ||||
Ribavirin | ||||
1.0 gm (patients ≤ 75 kg) | 20 (36.4%) | 4 (36.4%) | 16 (36.4%) | |
1.2 gm (patients >75 kg) | 15 (27.3%) | 3 (27.3%) | 12 (27.3%) | |
0.8 gm | 20 (36.4%) | 4 (36.4%) | 16 (36.4%) | |
IFN-α2b | 40 (42.1%) | 8 (42.1%) | 32 (42.1%) | NSS |
together with | ||||
Ribavirin | ||||
1.0 gm (patients ≤ 75 kg) | 10 (25.0%) | 2 (25.0%) | 8 (25.0%) | |
1.2 gm (patients >75 kg) | 10 (25.0%) | 2 (25.0%) | 8 (25.0%) | |
0.8 gm | 20 (50.0%) | 4 (50.0%) | 16 (50.0%) |