Table 4 Retinal Lesions and TCF7L2 rs7903146 genotype by hypertension or diabetes status in Caucasians
With Hypertension | Without Hypertension | With Diabetes | Without Diabetes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinal Lesion | n | No. with Lesion (%) | OR (95% CI)a | n | No. with Lesion (%) | OR (95% CI)a | n | No. with Lesion (%) | OR (95% CI)a | n | No. with Lesion (%) | OR (95% CI)a | |
AV nicking | CC | 1595 | 280 (17.55) | 1.00 | 2462 | 305 (12.39) | 1.00 | 525 | 89 (16.95) | 1.00 | 3533 | 496 (14.04) | 1.00 |
CT | 1297 | 222 (17.12) | 1.18 (1.02, 1.36) | 1989 | 211 (10.61) | 0.91 (0.78, 1.05) | 525 | 88 (16.76) | 0.99 (0.78, 1.26) | 2761 | 345 (12.50) | 1.04 (0.92, 1.16) | |
TT | 259 | 60 (23.17) | 1.39 (1.04, 1.86) | 430 | 46 (10.70) | 0.83 (0.61, 1.11) | 134 | 21 (15.67) | 0.98 (0.61, 1.58) | 555 | 85 (15.32) | 1.07 (0.85, 1.35) | |
P valueb | 0.03 | 0.21 | 0.94 | 0.56 | |||||||||
Focal arteriolar narrowing | CC | 1584 | 330 (20.83) | 1.00 | 2456 | 268 (10.91) | 1.00 | 519 | 88 (16.96) | 1.00 | 3522 | 510 (14.48) | 1.00 |
CT | 1290 | 320 (24.81) | 1.25 (1.09, 1.44) | 1978 | 223 (11.27) | 0.96 (0.82, 1.12) | 526 | 91 (17.30) | 0.85 (0.65, 1.11) | 2742 | 452 (16.48) | 1.18 (1.06, 1.32) | |
TT | 259 | 67 (25.87) | 1.56 (1.18, 2.06) | 429 | 37 (8.62) | 0.92 (0.68, 1.25) | 136 | 15 (11.03) | 0.73 (0.42, 1.24) | 552 | 89 (16.12) | 1.40 (1.12, 1.75) | |
P valueb | 0.002 | 0.59 | 0.24 | 0.003 | |||||||||
Retinopathy | CC | 1612 | 136 (8.44) | 1.00 | 2492 | 100 (4.01) | 1.00 | 534 | 78 (14.61) | 1.00 | 3571 | 158 (4.42) | 1.00 |
CT | 1311 | 112 (8.54) | 1.04 (0.85, 1.26) | 2010 | 93 (4.63) | 1.12 (0.90, 1.39) | 536 | 76 (14.18) | 1.05 (0.82, 1.34) | 2785 | 129 (4.63) | 1.01 (0.84, 1.22) | |
TT | 262 | 23 (8.78) | 1.08 (0.73, 1.60) | 433 | 22 (5.08) | 1.26 (0.81, 1.94) | 136 | 23 (16.91) | 1.10 (0.67, 1.8) | 559 | 22 (3.94) | 1.02 (0.70, 1.48) | |
P valueb | 0.71 | 0.31 | 0.71 | 0.91 | |||||||||