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Table 2 Retinal lesions by TCF7L2 rs7903146 genotype, by race

From: The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study

  

African American

Caucasian

Retinal Lesion

 

n

No. with Lesion (%)

OR (95% CI)a

P valueb

n

No. with Lesion (%)

OR (95% CI)a

P valueb

AV nicking

CC

1083

179 (16.53)

1.00

0.24

4058

585 (14.42)

1.00

0.58

 

CT

915

156 (17.05)

1.12 (0.93, 1.35)

 

3286

433 (13.18)

1.03 (0.93, 1.14)

 
 

TT

174

33 (18.97)

1.26 (0.86, 1.83)

 

689

106 (15.38)

1.06 (0.86, 1.30)

 

Focal arteriolar narrowing

CC

1076

136 (12.64)

1.00

0.40

4041

598 (14.80)

1.00

0.05

 

CT

912

120 (13.16)

1.10 (0.88, 1.36)

 

3268

543 (16.62)

1.11 (1.00, 1.23)

 
 

TT

173

26 (15.03)

1.20 (0.78, 1.85)

 

688

104 (15.12)

1.23 (1.00, 1.51)

 

Retinopathy

CC

1099

138 (12.56)

1.00

0.36

4105

236 (5.75)

1.00

0.27

 

CT

923

128 (13.87)

1.10 (0.90, 1.35)

 

3321

205 (6.17)

1.09 (0.94, 1.26)

 
 

TT

177

24 (13.56)

1.21 (0.81, 1.81)

 

695

45 (6.47)

1.18 (0.88, 1.58)

 
  1. Abbreviations: AV, arteriovenous; CI, confidence interval; OR, odds ratio. aAdjusted for age, study center, gender, current smoking (yes/no), obesity, total serum cholesterol, total serum triglycerides, mean arterial blood pressure, hypertension, and antihypertensive medication; b P value for OR in the log additive genetic model.