Figure 3

Tolbutamide response in SUR1-R1530C. Mean steady-state whole-cell K-ATP currents (as indicated) evoked by a voltage step from -10 to -30 mV before (rest; grey bars) and after application of 3 mmol/l azide (grey bars) and in the presence of 3 mmol/l azide plus 0.5 mmol/l tolbutamide (black bars). Four oocytes were used for each experiment. *P < 0.05against control (t-test).