Cancer and Endocrine Tumors

This section concerns all aspects of endocrine tumours and cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Case report

    Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report

    Adrenal corticomedullary mixed tumours are very rare. Its mechanism is rarely reported. Here we report the first case of a corticomedullary mixed tumour resembling a “small adrenal gland” with distinct arrange...

    Lian Duan, Fang Fang, Wanlei Fu, Zhenqiang Fang, Hui Wang, Shicang Yu, Zili Tang, Zhenqi Liu and Hongting Zheng

    BMC Endocrine Disorders 2017 17:9

    Published on: 13 February 2017

  2. Research article

    Utility of repeat cytological assessment of thyroid nodules initially classified as benign: clinical insights from multidisciplinary care in an Irish tertiary referral centre

    Fine needle aspiration biopsy (FNAB) is the tool of choice for evaluating thyroid nodules with the majority classified as benign following initial assessment. However, concern remains about false negative resu...

    Nigel Glynn, Mark J. Hannon, Sarah Lewis, Patrick Hillery, Mohammed Al-Mousa, Arnold D. K. Hill, Frank Keeling, Martina Morrin, Christopher J. Thompson, Diarmuid Smith, Derval Royston, Mary Leader and Amar Agha

    BMC Endocrine Disorders 2016 16:45

    Published on: 2 August 2016

  3. Research article

    Natural history and outcome in chinese patients with gastroenteropancreatic neuroendocrine tumours: - a 17-year retrospective analysis

    There is rising incidence of gastroenteropancreatic neuroendocrine tumours (GEP- NETs) in many parts of the world, but epidemiological data from Asian populations is rare.

    Doris T. Chan, Andrea O. Y. Luk, W. Y. So, Alice P. S. Kong, Francis C. C. Chow, Ronald C. W. Ma and Anthony W. I. Lo

    BMC Endocrine Disorders 2016 16:12

    Published on: 24 February 2016

  4. Research article

    Results of a prospective multicenter neuroendocrine tumor registry reporting on clinicopathologic characteristics of Greek patients

    The rare incidence of neuroendocrine neoplasms (NENs) has contributed to a paucity of large epidemiologic studies of patients with this condition. We investigated the occurrence and clinicopathologic features ...

    George C. Nikou, Kalliopi Pazaitou-Panayiotou, Dimitrios Dimitroulopoulos, Georgios Alexandrakis, Pavlos Papakostas, Michalis Vaslamatzis, Philippos Kaldrymidis, Vyron Markussis and Anna Koumarianou

    BMC Endocrine Disorders 2016 16:8

    Published on: 12 February 2016

  5. Case report

    Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report

    Aldosterone-producing adrenocortical carcinoma is a rare malignancy, which is usually diagnosed by histopathological examination of the excised tumor. In inoperable cases, aldosterone-producing ACC diagnosed b...

    Kennosuke Ohashi, Takeshi Hayashi, Masaya Sakamoto, Hiroyuki Iuchi, Hirofumi Suzuki, Takanori Ebisawa, Katsuyoshi Tojo, Hironobu Sasano and Kazunori Utsunomiya

    BMC Endocrine Disorders 2016 16:3

    Published on: 16 January 2016

  6. Research article

    A clinical prediction score for diagnosing unilateral primary Aldosteronism may not be generalizable

    A published clinical prediction score indicated that a unilateral adrenal adenoma and either hypokalemia or an estimated glomerular filtration rate of 100 ml/min/1.73 m2 was 100% specific for unilateral primar...

    Erik S Venos, Benny So, Valerian C Dias, Adrian Harvey, Janice L Pasieka and Gregory A Kline

    BMC Endocrine Disorders 2014 14:94

    Published on: 11 December 2014

  7. Research article

    The use of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of thyroid lesions

    Non-palpable thyroid nodules can be difficult to access by conventional ultrasound-guided fine needle aspiration, particularly when they are intrathoracic. Many of these patients are subject to multiple follow...

    Roberto F Casal, Mimi N Phan, Keerthana Keshava, Jose M Garcia, Horiana Grosu, D Ray Lazarus, Juan Iribarren and Daniel G Rosen

    BMC Endocrine Disorders 2014 14:88

    Published on: 22 November 2014

  8. Case report

    Testicular and inguinal lymph node metastases of medullary thyroid cancer: a case report and review of the literature

    The involvement of the testis by metastatic medullary thyroid carcinoma has never been described before. We describe the first case of metastatic medullary thyroid carcinoma affecting testis and inguinal lymph...

    Marialuisa Appetecchia, Agnese Barnabei, Vincenzo Pompeo, Steno Sentinelli, Roberto Baldelli, Salvatore Maria Corsello and Francesco Torino

    BMC Endocrine Disorders 2014 14:84

    Published on: 11 October 2014

  9. Case report

    Evolution in functionality of a metastatic pancreatic neuroendocrine tumour (pNET) causing Cushing’s syndrome: treatment response with chemotherapy

    We report the case of a patient who had a non-functional metastatic pancreatic neuroendocrine tumour (pNET), which changed in functionality during the course of the disease. This case demonstrates the effectiv...

    Surya Panicker Rajeev, Steffan McDougall, Monica Terlizzo, Daniel Palmer, Christina Daousi and Daniel J Cuthbertson

    BMC Endocrine Disorders 2014 14:70

    Published on: 24 August 2014

  10. Research article

    Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas

    Pancreatic neuroendocrine tumors (PNETs) are a group of rare tumors. Chromogranin A (CgA) was considered as the most practical and useful serum tumor marker in PNET patients. But peripheral blood levels of CgA...

    Xin-Wei Qiao, Ling Qiu, Yuan-Jia Chen, Chang-Ting Meng, Zhao Sun, Chun-Mei Bai, Da-Chun Zhao, Tai-Ping Zhang, Yu-Pei Zhao, Yu-Li Song, Yu-Hong Wang, Jie Chen and Chong-Mei Lu

    BMC Endocrine Disorders 2014 14:64

    Published on: 7 August 2014

  11. Case report

    Suspected metastatic adrenocortical carcinoma revealing as pulmonary Kaposi sarcoma in adrenal Cushing’s syndrome

    Kaposi sarcoma (KS) is a malignant disease most commonly diagnosed in the setting of a human immunodeficiency virus (HIV) infection and in patients receiving immunosuppressive treatment. Pulmonary KS has never...

    Margarita Bala, Cristina L Ronchi, Josef Pichl, Vanessa Wild, Stefan Kircher, Bruno Allolio and Stefanie Hahner

    BMC Endocrine Disorders 2014 14:63

    Published on: 30 July 2014

  12. Research article

    Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms

    Promyelocytic leukaemia zinc finger (PLZF) is a transcriptional repressor that was originally isolated from a patient with promyelocytic leukaemia. PLZF also affects key elements for cell cycle progression, su...

    Kazuhiko Matsuzawa, Shoichiro Izawa, Tsuyoshi Ohkura, Hiroko Ohkura, Kiyosuke Ishiguro, Akio Yoshida, Yumi Takiyama, Masakazu Haneda, Chiaki Shigemasa, Kazuhiro Yamamoto and Shin-ichi Taniguchi

    BMC Endocrine Disorders 2014 14:52

    Published on: 3 July 2014

  13. Case report

    Hypoglycemia mediated by paraneoplastic production of Insulin like growth factor–2 from a malignant renal solitary fibrous tumor – clinical case and literature review

    Hypoglycemic episodes are infrequent in individuals without a history of diabetes mellitus or bariatric surgery. When hypoglycemia does occur in such individuals, an uncommon but important diagnosis to conside...

    Ameer Khowaja, Brianna Johnson-Rabbett, John Bantle and Amir Moheet

    BMC Endocrine Disorders 2014 14:49

    Published on: 17 June 2014

  14. Research article

    Increased expression of ACTH (MC2R) and androgen (AR) receptors in giant bilateral myelolipomas from patients with congenital adrenal hyperplasia

    Although chronic adrenocorticotropic hormone (ACTH) and androgen hyperstimulation are assumed to be involved in the pathogenesis of adrenal myelolipomas associated with poor-compliance patients with congenital...

    Madson Q Almeida, Laura C Kaupert, Luciana P Brito, Antonio M Lerario, Beatriz M P Mariani, Marta Ribeiro, Osmar Monte, Francisco T Denes, Berenice B Mendonca and Tânia ASS Bachega

    BMC Endocrine Disorders 2014 14:42

    Published on: 12 May 2014

  15. Case report

    1,25-dihydroxyvitamin D and PTHrP mediated malignant hypercalcemia in a seminoma

    Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relat...

    René Rodríguez-Gutiérrez, Maria Azucena Zapata-Rivera, Dania Lizeth Quintanilla-Flores, Carlos Rodrigo Camara-Lemarroy, Fernando Javier Lavalle-Gonzalez, José Gerardo González-González and Jesús Zacarías Villarreal-Pérez

    BMC Endocrine Disorders 2014 14:32

    Published on: 10 April 2014

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