Basic and Clinical Endocrinology

Section edited by Amar Agha

This section concerns disorders of the pituitary axis and related organs and tissues; incuding specific disorders of the thyroid, adrenals, gonads etc. Articles concerning prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology are considered within this section.

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  1. Research article

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study

    Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrit...

    Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang and Mei Zhu

    BMC Endocrine Disorders 2017 17:10

    Published on: 17 February 2017

  2. Research article

    Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS: randomized trial

    Liraglutide 3 mg was recently approved as an anti-obesity drug. Metformin is weight neutral, yet it could enhance the therapeutic index of GLP-1 agonist. We compared weight-lowering potential of liraglutide 1....

    Mojca Jensterle, Nika Aleksandra Kravos, Katja Goričar and Andrej Janez

    BMC Endocrine Disorders 2017 17:5

    Published on: 31 January 2017

  3. Research article

    The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study

    To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis ...

    Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz and Mariusz Klencki

    BMC Endocrine Disorders 2016 16:69

    Published on: 1 December 2016

  4. Case report

    Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report

    Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout ...

    Ayumu Takeno, Masahiro Yamamoto, Masakazu Notsu and Toshitsugu Sugimoto

    BMC Endocrine Disorders 2016 16:66

    Published on: 24 November 2016

  5. Case report

    Case report of whole genome sequencing in the XY female: identification of a novel SRY mutation and revision of a misdiagnosis of androgen insensitivity syndrome

    The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicate...

    Sunita M. C. De Sousa, Karin S. Kassahn, Liam C. McIntyre, Chan-Eng Chong, Hamish S. Scott and David J. Torpy

    BMC Endocrine Disorders 2016 16:58

    Published on: 8 November 2016

  6. Research article

    Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

    Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TS...

    Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu and Jin-Kui Yang

    BMC Endocrine Disorders 2016 16:57

    Published on: 6 November 2016

  7. Research article

    Familial early puberty: presentation and inheritance pattern in 139 families

    The mechanism that initiates the onset of puberty is largely unknown but the age of onset is mainly under genetic control and influenced by environmental factors including nutrition. The coexistence in the sam...

    Adélaïde Durand, Anu Bashamboo, Ken McElreavey and Raja Brauner

    BMC Endocrine Disorders 2016 16:50

    Published on: 13 September 2016

  8. Research article

    Adrenal fatigue does not exist: a systematic review

    The term “adrenal fatigue” (“AF”) has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, “...

    Flavio A. Cadegiani and Claudio E. Kater

    BMC Endocrine Disorders 2016 16:48

    Published on: 24 August 2016

    The Erratum to this article has been published in BMC Endocrine Disorders 2016 16:63

  9. Case report

    Splicing analysis of CYP11B1 mutation in a family affected with 11β-hydroxylase deficiency: case report

    Congenital adrenal hyperplasia (CAH) due to steroid 11β-hydroxylase deficiency (11β-OHD) is a rare form of CAH associated with low renin hypertension, hypokalemia, hyperandrogenemia and ambiguous genitalia in ...

    Pattaranatcha Charnwichai, Patra Yeetong, Kanya Suphapeetiporn, Vichit Supornsilchai, Taninee Sahakitrungruang and Vorasuk Shotelersuk

    BMC Endocrine Disorders 2016 16:37

    Published on: 17 June 2016

  10. Research article

    Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study

    In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations pos...

    Geoffrey Omuse, Ali Kassim, Francis Kiigu, Syeda Ra’ana Hussain and Mary Limbe

    BMC Endocrine Disorders 2016 16:23

    Published on: 23 May 2016

  11. Research article

    Cost-effectiveness of tolvaptan for the treatment of hyponatraemia secondary to syndrome of inappropriate antidiuretic hormone secretion in Sweden

    Tolvaptan is the only vasopressin V2 receptor antagonist licensed by the European Medicines Agency for the treatment of hyponatraemia (HN) secondary to the syndrome of inappropriate antidiuretic hormone secretion...

    Clare Jamookeeah, Paul Robinson, Karl O’Reilly, Johan Lundberg, Martin Gisby, Michael Ländin, Jakob Skov and David Trueman

    BMC Endocrine Disorders 2016 16:22

    Published on: 16 May 2016

  12. Research article

    The haplotype of UBE2L3 gene is associated with Hashimoto’s thyroiditis in a Chinese Han population

    The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune th...

    Yu Wang, Yuan-feng Zhu, Qiong Wang, Jing Xu, Ni Yan, Jian Xu, Liang-feng Shi, Shuang-tao He and Jin-an Zhang

    BMC Endocrine Disorders 2016 16:18

    Published on: 19 April 2016

  13. Research article

    Switching patients with acromegaly from octreotide to pasireotide improves biochemical control: crossover extension to a randomized, double-blind, Phase III study

    Many patients with acromegaly do not achieve biochemical control with first-generation somatostatin analogues. A large, multicenter, randomized, Phase III core study demonstrated that pasireotide LAR had signi...

    Marcello D. Bronstein, Maria Fleseriu, Sebastian Neggers, Annamaria Colao, Michael Sheppard, Feng Gu, Chiung-Chyi Shen, Mônica Gadelha, Andrew J. Farrall, Karina Hermosillo Reséndiz, Matthieu Ruffin, YinMiao Chen and Pamela Freda

    BMC Endocrine Disorders 2016 16:16

    Published on: 2 April 2016

  14. Research article

    Plasminogen activator inhibitor-1 concentrations and bone mineral density in postmenopausal women with type 2 diabetes mellitus

    Women with type 2 diabetes mellitus (T2DM) have a higher risk of fractures despite increased bone mineral density (BMD). In experimental studies a potential role of plasminogen activator inhibitor-1 (PAI-1) in...

    Silvija Canecki-Varžić, Ivana Prpić-Križevac and Ines Bilić-Ćurčić

    BMC Endocrine Disorders 2016 16:14

    Published on: 3 March 2016

  15. Case report

    Optic glioma and precocious puberty in a girl with neurofibromatosis type 1 carrying an R681X mutation of NF1: case report and review of the literature

    Neurofibromatosis type 1 (NF1) is a common autosomal dominant genetic disorder with an extremely variable phenotype. In childhood NF1 can be associated with optic glioma and central precocious puberty; the lat...

    Mirjana Kocova, Elena Kochova and Elena Sukarova-Angelovska

    BMC Endocrine Disorders 2015 15:82

    Published on: 15 December 2015

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